A NEW METHOD FOR SYNTHESIZING THE ANTINEOPLASTIC NUCLEOSIDES 1-(2-AZIDO-2-DEOXY-β-D-ARABINOFURANOSYL)CYTOSINE (CYTARAZID) AND 1-(2-AMINO-2-DEOXY-β-D-ARABINOFURANOSYL)CYTOSINE (CYTARAMIN) FROM URIDINE
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概要
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A new method was developed for synthesizing of antineoplastic nucleosides 1-(2-azido-2-deoxy-β-D-arabinofuranosyl)cytosine (2) and 1-(2-amino-2-deoxy-β-D-arabinofuranosyl)-cytosine (3) from uridine. The reaction of N3-benzoyluridine derivative (5) with DPPA, triphenylphosphine and diethyl azodicarboxylate gave the desired 2'-azido-arabinosyl derivative (6), which was subsequently transformed to lead 2 and 3.
- 公益社団法人日本薬学会の論文
- 1989-06-25
著者
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上田 亨
Faculty of Pharmaceutical Science, Hokkaido University
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松田 彰
Faculty Of Pharmaceutical Sciences Hokkaido University
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上田 亨
Faculty Of Pharmaceutical Sciences Hokkaido University
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安岡 譲二
Faculty of Pharmaceutical Sciences, Hokkaido University
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上田 亨
北海道大学薬学部
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安岡 譲二
Faculty Of Pharmaceutical Sciences Hokkaido University
関連論文
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