Therapeutic Effect of Reticuloendothelial System (RES)-Avoiding Liposomes Containing a Phospholipid Analogue of 5-Fluorouracil, Dipalmitoylphosphatidylfluorouridine, in Meth A Sarcoma-Bearing Mice
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概要
- 論文の詳細を見る
Reticuloendothelial system (RES)-avoiding liposomes are known to accumulate in tumor tissues due to passive targeting. Dipalmitoylphosphatidylfluorouridine (DPPF), a potent antitumor agent readily incorporated into the lipid bilayer, was embedded in RES-avoiding liposomes modified with a uronic acid derivative, palmityl-D-glucuronide (PGlcUA). The therapeutic effect of DPPF in PGlcUA-liposomes was examined in tumor-bearing mice. Free or liposomal DPPF was injected intravenously into BALB/c mice bearing subcutaneously implanted Meth A sarcomas. The RES-avoiding liposomal formulation using PGlcUA was effective in reducing tumors, and prolonging survival time compared with free DPPF and also DPPF in conventional liposomes. Therefore, PGlcUA-liposomes might be of practical use as drug carriers for anticancer agents, especially their derivatives for embedding in liposomal membranes.
- 社団法人日本薬学会の論文
- 1994-10-15
著者
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周東 智
北海道大学大学院薬学研究院
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周東 智
Faculty of Pharmaceutical Sciences, Hokkaido University
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奥 直人
Dep. Of Medical Biochemistry School Of Pharmaceutical Sciences Univ. Of Shizuoka
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Oku Naoto
静岡県立大学 薬学部
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酒井 敦史
旭化成工業ライフサイエンス総合研究所
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奥 直人
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University
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岡田 昌二
Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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奥 直人
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Setsunan University
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Okada S
School Of Pharmaceutical Sciences University Of Shizuoka
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土井 香苗子
Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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豊田 敏志
Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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酒井 敦史
Institute for Life Science Research, Asahi Chemical Industry Co., Ltd.
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ITOH Hiromichi
Institute for Life Science Research, Asahi Chemical Industry Co., Ltd.
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土井 香苗子
静岡県立大学薬学部
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豊田 敏志
Department Of Radiobiochemistry School Of Pharmaceutical Sciences University Of Shizuoka
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Doi K
Department Of Radiobiochemistry School Of Pharmaceutical Sciences University Of Shizuoka
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Itoh Hiromichi
Institute For Life Science Research Asahi Chemical Industry Co. Ltd.
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