Suppressed Permeation of Linoleic Acid in a Liposomal Formulation through Reconstructed Skin Tissue(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
Since the liposomal formulation of linoleic acid (LA) exhibited an enhanced skin-whitening effect, the influence of liposomalization on the cutaneous absorption of LA was examined using a three-dimensional (3D) reconstructed skin model. Liposome entrapped [^<14>C]-LA was applied on the skin model, and the permeation of LA through the skin was monitored. The permeation rate of LA in the liposomal formulation was found to be lower than that in the conventional formulation without liposomes, suggesting the increased retention time of LA in the skin by the liposomal formulation. Next, to investigate the dependence of the LA permeation on melanocyte conditions and intactness of the reconstructed skin model, the effect of UV irradiation on LA permeation was examined. Low-dose UVB irradiation (0.03 J/cm^2 for 3 times), which activated melanocytes in the skin, did not influence the extent of LA permeation, while high-dose irradiation (0.30 J/cm^2 for 3 times) enhanced the permeation of LA in both the conventional and liposomal formulation. The present results suggest the importance of skin intactness for LA permeation and that the 3D reconstructed skin model would be useful for evaluating the characteristics of skin-oriented cosmetics and drugs.
- 公益社団法人日本薬学会の論文
- 2004-06-01
著者
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OKU Naoto
Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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奥 直人
Dep. Of Medical Biochemistry School Of Pharmaceutical Sciences Univ. Of Shizuoka
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Oku Naoto
静岡県立大学 薬学部
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奥 直人
静岡県立大学 薬学部 医薬生命化学教室
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Oku N
Univ. Shizuoka Shizuoka Jpn
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IMANAKA Hiromichi
R&D Center, Sunstar Inc.
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MAKINO Taketoshi
R&D Center, Sunstar Inc.
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Oku Naoto
Department Of Medical Biochemistry And Coe Program In The 21st Century University Of Shizuoka School
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Baba N
Graduate School Of Natural Science And Technology Okayama University
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Baba Naomichi
Department Of Bioresources Chemistry Faculty Of Agriculture Okayama University
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BABA Naomichi
Okayama University, Faculty of Agriculture
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SHIGETA Yasutami
Okayama University Graduate School of Natural Science and Technology
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YONEZAWA Sei
Department of Medical Biochemistry, University of Shizuoka School of Pharmaceutical Sciences
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Makino Taketoshi
R&d Division Sunstar Inc.
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Imanaka Hiromichi
Department Of Medical Biochemistry Graduate School Of Pharmaceutical Sciences University Of Shizuoka
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Yonezawa Sei
Department Of Medical Biochemistry And Coe Program In The 21st Century School Of Pharmaceutical Scie
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Yonezawa S
Department Of Medical Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences
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Baba Naomichi
Div. Of Bioscience Graduate School Of Natural Sci. And Technol. Okayama Univ.
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Makino T
Department Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Kyoto University
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奥 直人
静岡県立大学薬学部医薬生命科学教室
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Makino Toshiaki
R&d Division Sunstar Inc.
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Shigeta Y
Department Of Bioresources Chemistry Faculty Of Agriculture Okayama University:r&d Center Sunsta
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OKU Naoto
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University
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