サポニンによる好中球の活性化
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概要
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The effect of saponins on the one of major functions of neutrophil, namely the generation of superoxide anion (O_2^-), was investigated using retinoic acid (RA)-differentiated HL-60 cells (promyelocytic leukemia cells). The generation of O_2^- from the cells induced by saponins was monitored by the reduction of cytochrome c. All five species of crude saponins studied here, i.e. tea-leaf saponins, tea-seed saponins, ginsenosides, soyasaponins and saikosaponins, stimulated the generation of O_2^- from RA-differentiated HL-60 cells. Tea-leaf saponins showed the highest stimulating activity, followed by soyasaponins and ginsenosides. The cytotoxic activity of saponins was determined by the dye exclusion method after the incubation of RA-differentiated HL-60 cells with various concentrations of saponins. Saikosaponins and tea-seed saponins exhibited considerable cytotoxic activity and hemolytic activity. To examine the involvement of protein kinase C (PKC) in the neutrophil activation by saponins, the effect of H-7,an antagonist of PKC, on the generation of O_2^- induced by saponins was investigated. H-7 was found to inhibit the generation of O_2^- in a dose-dependent manner, suggesting the participation of PKC in the neutrophil stimulating process by saponins. Tea-leaf saponins, ginsenosides and soyasaponins, which had high neutrophil stimulating activity and low cytotoxic activity, seemed to be useful as a biological response modifier (BRM) for the activation of neutrophil.
- 1995-07-25
著者
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提坂 裕子
(株)伊藤園中央研究所
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奥 直人
静岡県立大学大学院薬学研究科医薬生命化学講座
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奥 直人
Dep. Of Medical Biochemistry School Of Pharmaceutical Sciences Univ. Of Shizuoka
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Oku Naoto
静岡県立大学 薬学部
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岡田 昌二
静岡県立大学薬学部
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奥 直人
静岡県立大学 薬学部
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Okada S
School Of Pharmaceutical Sciences University Of Shizuoka
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堤坂 裕子
(株)伊藤園中央研究所
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植村 照美
(株)伊藤園中央研究所
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提坂 裕子
株式会社伊藤園 中央研究所
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岡田 昌二
静岡県立大学
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