Chronopharmacologic Cancer Treatment with an Angiogenic Vessel-Targeted Liposomal Drug(Biopharmacy)
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概要
- 論文の詳細を見る
Antineovascular therapy (ANET), which eradicates angiogenic endothelial cells by specifically delivered anticancer drugs to tumor cells to obtain complete cutoff of blood supply, is an effective modality for cancer treatment. Since the expression of vascular endothelial growth factor (VEGF) in hypoxic tumor cells is known to fluctuate in a circadian oscillation, we investigated the chronopharmacologic treatment of tumors with ANET. Adriamycin-encapsulated liposomes modified with the Ala-Pro-Arg-Pro-Gly (APR-PG) peptide (APRPG-LipADM) were prepared, after the APRPG peptide had been shown to have affinity to angiogenic sites. Colon 26 NL-17 tumor-bearing mice were injected three times with APRPG-LipADM at Zeitgeber time (ZT) 2, 8, 14, and 20 where ZT 0 was the time lights were turned on, and tumor growth was monitored. Tumor growth suppression changed with dosing time and was significantly (p<0.01) more potent at ZT 14 compared with ZT 20. The VEGF concentration in the plasma of the tumor-bearing mice was higher in the light phase compared with that in the dark phase, and this circadian oscillation was related to dosing time dependency with ANET. These results indicate that tumor growth suppression is correlated to some extent with the VEGF concentration in the plasma, and that chronopharmacologic treatment of cancer with ANET may enhance the therapeutic efficacy and reduce the side effects.
- 公益社団法人日本薬学会の論文
- 2008-01-01
著者
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TANAKA Toshiki
Department of Neurosurgery, Asahi University Murakami Memorial Hospital
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ASAI Tomohiro
Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry, and
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OKU Naoto
Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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奥 直人
Dep. Of Medical Biochemistry School Of Pharmaceutical Sciences Univ. Of Shizuoka
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Oku Naoto
静岡県立大学 薬学部
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奥 直人
静岡県立大学大学院薬学研究科
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奥 直人
静岡県立大学 薬学部 医薬生命化学教室
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Oku N
Univ. Shizuoka Shizuoka Jpn
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Shimizu K
Department Of Pharmaceutics Hoshi University
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Oku Naoto
Department Of Medical Biochemistry And Coe Program In The 21st Century University Of Shizuoka School
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Asai Tomohiro
Department Of Medical Biochemistry And Global Coe University Of Shizuoka School Of Pharmaceutical Sc
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Asai T
Department Of Medical Biochemistry And Coe Program In The 21st Century University Of Shizuoka School
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Asai Tomohiro
Department Of Cardiovascular Surgery Okayama University Graduate School Of Medicine Dentistry And Ph
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Asai Tomohiro
Department Of Medical Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences
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SHIMIZU Kosuke
Department of Medical Biochemistry and COE Program in the 21st Century, School of Pharmaceutical Sci
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Tanaka Toshiki
Department Of Applied Chemistry Faculty Of Engineering Nagoya Institute Of Technology
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Shimizu Kosuke
Department Of Medical Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences
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奥 直人
静岡県立大学薬学部医薬生命科学教室
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SAWAZAKI Yasuharu
Department of Medical Biochemistry, University of Shizuoka School of Pharmaceutical Sciences
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Sawazaki Yasuharu
Department Of Medical Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences
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OKU Naoto
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University
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