Digital Radiographic Quantification of Myocardial Blood Flow Around a Transmyocardial Laser Channel in Rabbit Hearts
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概要
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Background A mechanism underlying the benefits of transmyocardial laser revascularization (TMLR) has been presumed to be improvement in perfusion. We evaluated myocardial blood flow around a laser channel using digital radiography combined with a ^3H-labeled desmethylimipramine ([^3H]DMI) deposition. Methods and Results A laser channel was created in the left ventricular wall using a YAG-laser in 6 nonischemic rabbit hearts. After 8 weeks, [^3H]DMI(1.11 MBq) was injected into the left atrium and the TMLR-treated myocardium was sectioned. Another 6 hearts were examined as controls. We measured [^3H]DMI density in arbitrary units with digital radiography in the channel remnant, the surrounding area and a remote area. Flow distribution was quantified by the coefficient of variation of flows (CV). The surrounding area had the highest density (p<0.001) and the lowest CV (p<0.001), and had higher density (p<0.001) and lower CV (p<0.001) than the controls. There was no transmural difference in the density in all domains. The CV increased with depth in the remote area, as well as in controls (p<0.001), but there was no transmural difference in the surrounding area. Conclusions The TMLR increases myocardial blood flow and decreases flow heterogeneity in the surrounding area. The disappearance of transmural difference in flow heterogeneity might indicate the remodeling of microcirculation to improve regional oxygen delivery.
- 社団法人日本循環器学会の論文
- 2005-03-20
著者
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ASAI Tomohiro
Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry, and
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ISHINO Kozo
Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry, and
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SANO Shunji
Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry, and
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YAMAMOTO Shu
Department of Cardiovascular Surgery, Kure Kyosai Hospital
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Sano Shunji
Department Of Cardiovascular Surgery Okayama University Graduate School Of Medicine Dentistry And Ph
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Sano Shunji
Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutical Sci. Okayama Jpn
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Kajiya Fumihiko
Department of Medical Engineering & Systems Cardiology, Kawasaki Medical School
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Ishino Kozo
Department Of Cardiovascular Surgery Okayama University Graduate School Of Medicine Dentistry And Ph
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Ishino Kozo
Department Of Cardiovascular Surgery Okayama University Graduate School Of Medicine And Dentistry
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Asai Tomohiro
Department Of Cardiovascular Surgery Okayama University Graduate School Of Medicine Dentistry And Ph
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MATSUMOTO Takeshi
Department of Hematology, Mie University Graduate School of Medicine
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Kajiya Fumihiko
Kawasaki University of Medical Welfare
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Honjo Osami
Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine and Dentistry
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Kajiya Fumihiko
Department Of Medical Engineering And Systems Cardiology
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Kajiya Fumihiko
Dept. Of Medical Engineering And Systems Cardiology Kawasaki Medical School
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Kajiya Fumihiko
Department Of Cardiovascular Physiology Okayama University
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Kajiya Fumihiko
Department Of Medical Engineering And Systems Cardiology Kawasaki Medical School
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Kohmoto Takushi
Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine and Dentistry
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Matsumoto Takeshi
Department Of Biomechanical Engieering Graduate School Of Engineering Scien
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Sano Shunji
Department Of Cardiovascular Surgery Dentistry And Pharmaceutical Science Okayama University Graduat
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Honjo Osami
Department Of Cardiovascular Surgery Okayama University Graduate School Of Medicine And Dentistry
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Honjo Osami
Department Of Cardiovascular Surgery Okayama University Graduate School Of Medicine Dentistry And Ph
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Yamamoto Shu
Department Of Cardiovascular Surgery Okayama University Graduate School Of Medicine And Dentistry
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Yamamoto Shu
Department Of Cardiovascular Surgery Kure Kyosai Hospital
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Kohmoto Takushi
Department Of Cardiovascular Surgery Okayama University Graduate School Of Medicine And Dentistry
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Kajiya Fumihiko
Department Of Cardiovascular Physiology Okayama University Graduate School Of Medicine And Dentistry
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Kajiya Fumihiko
Department Of Cardiovascular Physiology Okayama University Graduate School Of Medicine And Dentistry
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Kajiya Fumihiko
Department Of Medical Engineering Kawasaki Medical School
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Sano Shunji
Department Of Cardiovascular Surgery
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Kohmoto Takusi
Department Of Cardiovascular Surgery School Of Medicine Okayama University
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Yamamoto Shu
Cardiovascular Center Showa University Northern Yokohama Hospital
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Kajiya Fumihiko
Department Of Cardiovascular Physiology Okayama University Graduate School Of Medicine And Dentistry
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Matsumoto Takeshi
Department Of Medical Engineering And Systems Cardiology Kawasaki Medical School:department Of Mecha
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Matsumoto Takeshi
Department Of Biology Faculty Of Science Kumamoto University
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Sano Shunji
Department Of Cardiovascular Surgery Dentistry And Pharmaceutical Science Okayama University Graduat
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Kajiya Fumihiko
Department Of Cardiovascular Physiology Okayama University Graduate School Of Medicine And Dentistry:department Of Medical Engineering And Systems Cardiology Kawasaki Medical School
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