Effects of HMGB1 on Ischemia-Reperfusion Injury in the Rat Heart
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概要
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Background Coronary ischemia-reperfusion (I/R) injury causes cardiomyocyte necrosis in a multi-step process that includes an inflammatory reaction. A recent study has suggested that high-mobility group box 1 (HMGB1) is a late mediator of lethal sepsis and an early mediator of inflammation and necrosis following I/R injury. In the present study a neutralizing monoclonal antibody (mAb) for HMGB1 was used to clarify the role of HMGB1 in cardiac I/R injury. Methods and Results Rats underwent 30 min of left coronary artery occlusion followed by 60 min reperfusion. An intravenous injection of anti-HMGB 1 mAb or control IgG was administered just before reperfusion. The infarct size was enlarged in the anti-HMGB 1 mAb group in comparison with the control group (p<0.05). The treatment of anti-HMGB 1 mAb significantly increased the plasma troponin-T and norepinephrine (NE) content in the heart in comparison with the control (p<0.05). Moreover, the production of dihydroxyphenylglycol was reduced in the anti-HMGB 1-treated group (p<0.05). Conclusion This study shows for the first time the effects of treatment with neutralizing anti-HMGB 1 mAb on I/R injury in the rat heart. The findings support the novel view that I/R-induced HMGB 1 may be an important factor in the modulation of interstitial NE.
- 2008-06-20
著者
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SANO Shunji
Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry, and
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TAKAHASHI Hideo
Department of Electronics Engineering, Faculty of Engineering, Shibaura Institute of Technology
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Kanke Toru
Department Of Pharmacology University Of Okayama Graduate School Of Medicine Dentistry And Pharmaceu
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Kanke Toru
岡山大学 医歯薬学総合研究科心臓血管外科
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Kanke Toru
Department Of Pharmacology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutic
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Asanuma Masato
Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry
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Miyazaki Ikuko
Department Of Brain Science University Of Okayama Graduate School Of Medicine Dentistry And Pharmace
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Asanuma Masato
Department Of Brain Science Okayama University Graduate School Of Medicine And Dentistry
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Asanuma Masato
Department Of Brain Science University Of Okayama Graduate School Of Medicine Dentistry And Pharmace
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LIU Keyue
Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceu
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NISHIBORI Masahiro
Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceu
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Liu Keyue
Department Of Pharmacology University Of Okayama Graduate School Of Medicine Dentistry And Pharmaceu
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Oozawa Susumu
Department of Cardiovascular Surgery, University of Okayama Graduate School of Medicine, Dentistry a
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Mori Shuji
School of Pharmacy, University of Shujitsu
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Tomono Yasuko
Shigei Medical Institute
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Sano Shunji
Department Of Cardiovascular Surgery University Of Okayama Graduate School Of Medicine Dentistry And
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Takahashi Hideo
Department Of Pharmacology University Of Okayama Graduate School Of Medicine Dentistry And Pharmaceu
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Liu Keyue
Department Of Pharmacology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutic
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Mori Shuji
School Of Pharmacy University Of Shujitsu
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Mori Shuji
Department Of Pharmacology Okayama University Graduate School Of Medicine And Dentistry
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Oozawa Susumu
Department Of Cardiovascular Surgery University Of Okayama Graduate School Of Medicine Dentistry And
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Sano Shunji
Department Of Cardiovascular Surgery
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Takahashi H
Department Of Pharmacology Okayama University Graduate School Of Medicine And Dentistry
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Miyazaki Ikuko
Department Of Brain Science Okayama University Graduate School Of Medicine And Dentistry
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Nishibori M
Department Of Pharmacology University Of Okayama Graduate School Of Medicine Dentistry And Pharmaceu
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Takahashi Hideo
Department Of Biochemistry School Of Medicine Nihon University
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Takahashi Hideo
Department Of Anatomy Dokkyo Medical University School Of Medicine
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Nishibori Masahiro
Department Of Pharmacology Okayama University Graduate School Of Medicine And Dentistry
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MORI Shuji
School of Health Sciences, Okayama University
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