Alleviation of Ischemia-Induced Brain Edema by Activation of the Central Histaminergic System in Rats

スポンサーリンク

概要

• 論文の詳細を見る

• We have reported that facilitation of central histaminergic activity prevents the development of ischemia-induced brain injury. Since cerebral edema is a major cause of brain damage, we studied effects on brain edema of postischemic administration of <sc>L</sc>-histidine, a precursor of histamine, and thioperamide, a histamine H3–receptor antagonist, both of which enhance central histaminergic activity. Focal cerebral ischemia for 2 h was provoked by transient occlusion of the right middle cerebral artery in rats, and the water content and infarct size were determined 24 h after reperfusion. Changes in the extracellular concentration of histamine were examined in the striatum by a microdialysis procedure, and effects of these compounds were evaluated. Repeated administration of <sc>L</sc>-histidine (1000 mg/kg × 2, i.p.), immediately and 6 h after reperfusion, reduced the increase in the water contents in ischemic regions. Simultaneous administration of thioperamide (5 mg/kg, s.c.) with <sc>L</sc>-histidine (1000 mg/kg, i.p.) completely prevented edema formation and alleviated brain infarction, although a single dose of <sc>L</sc>-histidine, immediately after reperfusion, showed no benefits. The striatal histamine level was gradually increased after reperfusion as well as during ischemia. Simultaneous administration of thioperamide with <sc>L</sc>-histidine markedly increased the brain histamine concentration, and the value increased up to 230% of that in the saline group 5 – 6 h after reperfusion. <sc>L</sc>-Histidine alone did not affect the increase in the histamine output after ischemia. These findings suggest that urther activation of the central histaminergic system after initiation of cerebral ischemia prevents development of ischemia-induced brain edema.

• 2008-09-20

著者

• LIU Keyue

  Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceu

• Adachi Naoto

  Mabuchi Clinic

• Liu Keyue

  Department Of Pharmacology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutic

• IRISAWA Yumi

  Department of Anesthesiology and Resuscitology, Ehime University Graduate School of Medicine

• ARAI Tatsuru

  Kurashiki Medical Center

• NAGARO Takumi

  Department of Anesthesiology and Resuscitology, Ehime University Graduate School of Medicine

• Nagaro Takumi

  Department Of Anesthesiology & Resuscitology Ehime University School Of Medicine

• Irisawa Yumi

  Department Of Anesthesiology And Resuscitology Ehime University Graduate School Of Medicine

関連論文

• Effects of HMGB1 on Ischemia-Reperfusion Injury in the Rat Heart
• Adenosine A_2A-Receptor Stimulation Inhibits Lipopolysaccharide-Induced Interleukin-18 Production in Monocytes
• Adenosine A2A-Receptor Stimulation Inhibits Lipopolysaccharide-Induced Interleukin-18 Production in Monocytes
• Alleviation of Ischemia-Induced Brain Edema by Activation of the Central Histaminergic System in Rats
• Survey of patients whose lungs could not be ventilated and whose trachea could not be intubated in university hospitals in Japan
• Misplacement of an epidural catheter via intervertebral foramen is not rare
• Bilateral brachial plexus injury after liver transplantation
• The patency of the airway via each upper airway orifice during general anesthesia
• The Effect of Prior Nerve Block on Neuropathic Pain Induced by Partial Sciatic Nerve Injury in Rats
• The Repeatability of Hargreaves' Plantar Test in the Normal Rat

スポンサーリンク