Adenosine A2A-Receptor Stimulation Inhibits Lipopolysaccharide-Induced Interleukin-18 Production in Monocytes
スポンサーリンク
概要
- 論文の詳細を見る
Adenosine inhibited interleukin (IL)-18 production in lipopolysaccharide (LPS)-stimulated monocytes. The action of adenosine was antagonized by an adenosine A2A-receptor (A2AR) antagonist and was mimicked by an A2AR agonist, suggesting that the stimulation of A2AR may be involved in the actions of adenosine. On the other hand, the stimulation of A1R and A3R inhibited the actions of A2AR stimulation, whereas the stimulation of A2BR had no effect on them. Activation of A2AR is known to increase cyclic adenosine monophosphate (cAMP) levels and to activate protein kinase A (PKA). A PKA inhibitor prevented the actions of A2AR stimulation, indicating that the action mechanism of A2AR stimulation may be via the activation of the cAMP/PKA pathway.
- 社団法人 日本薬理学会の論文
著者
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YOSHINO Tadashi
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutica
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Sendo Toshiaki
Department Of Hospital Pharmacy Okayama University Medical And Dental School
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TANAKA NORIAKI
Department of Surgery, Okayama University School of Medicine
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TAKAHASHI Hideo
Department of Electronics Engineering, Faculty of Engineering, Shibaura Institute of Technology
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Kanke Toru
Department Of Pharmacology University Of Okayama Graduate School Of Medicine Dentistry And Pharmaceu
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Kanke Toru
岡山大学 医歯薬学総合研究科心臓血管外科
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Kanke Toru
Department Of Pharmacology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutic
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Sendo Toshiaki
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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KOHKA TAKAHASHI
Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceu
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LIU Keyue
Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceu
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NISHIBORI Masahiro
Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceu
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Liu Keyue
Department Of Pharmacology University Of Okayama Graduate School Of Medicine Dentistry And Pharmaceu
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Liu Keyue
Department Of Pharmacology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutic
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Kohka Takahashi
Department Of Pharmacology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutic
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Tanaka Noriaki
Department Of Gastroenterological Surgery Okayama University Graduate School Of Medicine Dentistry A
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Yoshino Tadashi
Department Of Hematology Okayama Rosai Hospital
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Tanaka Noriaki
Department Of Cardiovascular Physiology Okayama University
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Takahashi Hideo
Department Of Anatomy Dokkyo Medical University School Of Medicine
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Nishibori Masahiro
Department Of Pharmacology Okayama University Graduate School Of Medicine And Dentistry
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Yoshino Tadashi
Department Of Cytopathology Ayabe City Hospital
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Nishibori Masahiro
Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan
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Sendo Toshiaki
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Takahashi Hideo
Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan
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Tanaka Noriaki
Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan
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Kanke Toru
Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan
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Yoshino Tadashi
Department of Chemical Engineering, Hiroshima University
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