Different Histopathological Types of Orbital Lymphoma 16 Years after Systemic Follicular Lymphoma : Immunohistochemical and Immunogenetic Analyses of Two Cases
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概要
- 論文の詳細を見る
The purpose of this study is to show that the histopathological type of an orbital lymphoma can differ from the systemic follicular lymphoma that precedes it. A 44-year-old man (Patient #1) and a 50-year-old man (Patient #2) presented with generalized lymphadenopathy due to grade 1 follicular lymphoma proven on lymph node biopsy. Patient #1 was followed without treatment for 16 years when he developed a right orbital mass. Patient #2 underwent several courses of combination chemotherapy as well as radiation but relapsed. The second biopsy of the lymph node nine years later showed the same histopathological type of follicular lymphoma. He developed an orbital mass on the right side 16 years after the initial presentation. In Patient #1, excisional biopsy of the orbital masses showed extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). In Patient #2, biopsy revealed the orbital mass to be T-cell/histiocyte-rich diffuse large B-cell lymphoma. In Patient #1, when comparing the original lymph node biopsy to the orbital biopsy obtained years later, no evidence for clonality was noted by polymerase chain reaction. In Patient #2, the amplification by polymerase chain reaction of the immunoglobulin heavy chain gene rearrangement in the lymph node lesion and the orbital lesion gave rise to a single discrete band with the same DNA sequence except for five nucleotide changes, indicating the same clonality in the presence of genomic changes. In conclusion, orbital lymphomas can occur as a second lymphoma with a different histopathological type in the long-term follow-up of systemic lymphomas. The original and subsequent lymphomatous lesions may or may not share neoplastic cell clonality and all genomics. [J Clin Exp Hematopathol 48(1) : 17-24, 2008]
- 日本リンパ網内系学会の論文
- 2008-05-01
著者
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YOSHINO Tadashi
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutica
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ICHIMURA Kouichi
Department of Pathology, Okayama University Medical School and Graduate School of Medicine, Dentistr
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SHINAGAWA Katsuji
Department of Hematology/Oncology, Okayama University Medical School and Graduate School of Medicine
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Matsuo Toshihiko
Department Of Radiology Osaka City University Graduate School Of Medicine
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Yoshino T
Division Of Pathology Okayama University Hospital
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Yoshida Takashi
Department Of Pathology Okayama University
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Ichimura Koichi
Department Of Hematology And Rheumatology Tohoku University Graduate School Of Medicine
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Shinagawa Katsuji
Department Of Hematology/oncology Okayama University Medical School And Graduate School Of Medicine
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Morito Toshiaki
Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Itoh Kuniaki
Hematology And Oncology Division National Cancer Center Hospital East
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Ichimura Koichi
Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Yoshino Tadashi
岡山大学 医歯薬学総合研究科眼科学分野
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Shinagawa Katsuji
Department Of Biopathological Science Okayama University Graduate School Of Medicine And Dentistry
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Ichimura Koichi
Department Of Pathology Okayama University Graduate School Of Medicine And Dentistry
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Ichimura Koichi
Department Of Pathology And Molecular Diagnostics Aichi Cancer Center
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Ichimura Kouichi
Department Of Pathology Okayama University Medical School And Graduate School Of Medicine Dentistry
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Ichimura Kouichi
Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Matsuo Toshihiko
Department Of Ophthalmology Okayama University Medical School And Graduate School Of Medicine Dentis
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Matsuo Toshihiko
Department Of Ophthalmology National Hospital Organization Matsumoto Hospital
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Yoshino Tadashi
Department Of Pathology Okayama University
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Yoshino Tadashi
Department Of Hematology Okayama Rosai Hospital
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Tamada Yasuhiko
Department Of Dermatology Aichi Medical University Hospital
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Yoshino Tadashi
Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Yoshino Tadashi
Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Matsuo Toshihiko
Department Of Communications And Integrated Systems Tokyo Institute Of Technology
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Matsuo Toshihiko
Department Of Ophthalmology Okayama University Graduate School Of Medicine Dentistry And Pharmaceuti
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Yoshino Tadashi
Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Yoshino Tadashi
Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Yoshino Tadashi
Department Of Cytopathology Ayabe City Hospital
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Yoshino Tadashi
Department of Chemical Engineering, Hiroshima University
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