α7 Nicotinic Acetylcholine Receptor Stimulation Inhibits Lipopolysaccharide-Induced Interleukin-18 and -12 Production in Monocytes
スポンサーリンク
概要
- 論文の詳細を見る
Nicotine inhibited interleukin (IL)-18 and -12 production in lipopolysaccharide (LPS)-stimulated monocytes, and the action of nicotine was antagonized by a non-selective and a selective α7 nicotinic acetylcholine receptor (α7-nAChR) antagonist, suggesting that the stimulation of α7-nAChR may be involved in the action of nicotine. Nicotine is reported to induce prostaglandin E2 (PGE2) production in monocytes through the up-regulation of cyclooxygenase (COX)-2 expression. PGE2 is known to increase cAMP levels and to activate protein kinase A (PKA). COX-2 and PKA inhibitors prevented the action of nicotine, indicating that the mechanism of action of nicotine may be via endogenous PGE2 production.
- 社団法人 日本薬理学会の論文
- 2006-09-20
著者
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YOSHINO Tadashi
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutica
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TANAKA NORIAKI
Department of Surgery, Okayama University School of Medicine
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KOHKA TAKAHASHI
Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceu
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NISHIBORI Masahiro
Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceu
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Tanaka Naoko
Department Of Pediatrics Nagoya University School Of Medicine
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Tanaka N
Department Of Gastroenterological Surgery Okayama University Graduate School Of Medicine Dentistry A
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Yoshino Tadashi
Dep. Of Pathology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Jp
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Isozaki Hiroshi
Department Of Gastroenterological Surgery Okayama University Graduate School Of Medicine Dentistry A
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Terada N
Department Of Surgery Okayama University School Of Medicine
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Terada N
Department Of Gastroenterological Surgery Okayama University Graduate School Of Medicine Dentistry A
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IWAGAKI Hiromi
Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Okayama University Gra
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Iwagaki Hiromi
Department Of Gastroenterological Surgery Okayama University Graduate School Of Medicine Dentistry A
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Tanaka Nobutaka
Department Of Gastroenterology Institute Of Clinical Medicine The University Of Tsukuba
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Yagi Takahito
Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Kohka Takahashi
Department Of Pharmacology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutic
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Tanaka Noriaki
Department Of Gastroenterological Surgery Okayama University Graduate School Of Medicine Dentistry A
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HAMANO Ryosuke
Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry
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Yoshino Tadashi
Department Of Hematology Okayama Rosai Hospital
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Hamano Ryosuke
Department Of Gastroenterological Surgery Okayama University Graduate School Of Medicine Dentistry A
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Tanaka Noriaki
Department Of Cardiovascular Physiology Okayama University
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Tanaka Naomi
Department Of Gastroenterology Institute Of Clinical Medicine University Of Tsukuba
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Yagi Takahito
Department Of Gastroenterological Surgery Okayama University Graduate School Of Medicine And Dentist
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Nishibori M
Department Of Pharmacology University Of Okayama Graduate School Of Medicine Dentistry And Pharmaceu
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Tanaka Noriaki
Department Of Gastroenterological Surgery Transplant And Surgical Oncology Graduate School Of Medici
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Nishibori Masahiro
Department Of Pharmacology Okayama University Graduate School Of Medicine And Dentistry
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Tanaka Noriaki
Department Of Gastroenterological Surgery Okayama University Graduate School Of Medicine Dentistry A
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Yoshino Tadashi
Department Of Cytopathology Ayabe City Hospital
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Yoshino Tadashi
Department of Chemical Engineering, Hiroshima University
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Iwagaki Hiromi
Department of Gastroenterological Surgery and Transplant, Okayama University Graduate School of Medicine and Dentistry
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