Affinity Purification of Macrophage Migration Inhibitory Factor/Glycosylation Inhibiting Factor (MIF/GIF) from Bovine Brain by Using a Peptide Ligand Derived from a Novel Serpin
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概要
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We purified macrophage migration inhibitory factor/glycosylation inhibiting factor (MIF/GIF) from bovine brain by using an affinity column with the C-terminal region peptide of a novel serpin as a ligand. The affinity purified preparation showing a single band on SDS-PAGE contained four peptides on RP-HPLC, which were converged into two peptides time-dependently. Sequence analysis and Western blotting revealed that one was identical to bovine MIF/GIF and the other was an N-terminally modified form of MIF/GIF. These results indicated that there exist at least two forms of MIF/GIF in the bovine brain and that they have an affinity for the C-terminal portion of the serpin.
- 社団法人 日本薬理学会の論文
著者
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Nakaya Naoki
岡山大学 薬理
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NAKAYA Naoki
Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine
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NISHIBORI Masahiro
Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceu
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Mori S
Shimizu Pharmaceutical Co. Ltd. Shizuoka Jpn
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Mori Shuji
School of Pharmacy, University of Shujitsu
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KAWABATA MASAHIRO
Department of Surgery, Kurume University School of Medicine
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Mori Shuji
School Of Pharmacy University Of Shujitsu
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SAEKI Kiyomi
Department of Pharmacology, Okayama University Medical School
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Saeki Kiyomi
Department Of Pharmacology Okayama University Medical School
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Nakaya Naoki
Department Of Pharmacology Okayama University Medical School
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TAHARA Akihito
Department of Pharmacology, Okayama University Medical School
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Tahara Akihito
Department Of Pharmacology Okayama University Medical School
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Kawabata Masahiro
Department Of Pathology Kurume University School Of Medicine
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Kawabata Masahiro
Department Of Pharmacology Okayama University Medical School
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Kawabata Masahiro
Department Of Biochemistry The Cancer Institute Of Japanese Foundation For Cancer Research (jfcr) An
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Nishibori Masahiro
Department Of Pharmacology Okayama University Medical School
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Nishibori Masahiro
Department Of Pharmacology Okayama University Graduate School Of Medicine And Dentistry
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Nakaya Naoki
Department Of Medical Oncology Kanazawa Medical University
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MORI Shuji
School of Health Sciences, Okayama University
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