Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs) : PAR-2-Mediated Proliferation of Colon Cancer Cell
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概要
- 論文の詳細を見る
Proteinase-activated receptor-2 (PAR-2) has been demonstrated to be highly expressed in the gastrointestinal tract. In the present minireview, we summarize the effects of PAR-1 and PAR-2 stimulation using their activating peptides and agonist proteinases on the calcium signaling and the cell proliferation in DLD-1 cell, a human colon cancer cell line. PAR-2 but not PAR-1 stimulation induced the enhancement of cell proliferation, whereas both PAR-1 and PAR-2 stimulation induced the transient increase in [Ca2+]i. PAR-2 stimulation induced the phosphorylation of MEK1/2 and ERK1/2, but PAR-1 stimulation did not. The inhibition of MEK1/2 by PD98059 completely abolished the proliferative response to PAR-2 stimulation. Thus, MEK-ERK activation plays major role in the PAR-2-mediated proliferative response. The coupling of PARs to calcium signaling and MEK-ERK activation may be independent, and varied dependent on cell types.
- 社団法人 日本薬理学会の論文
- 2005-01-20
著者
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TAKAHASHI Hideo
Department of Electronics Engineering, Faculty of Engineering, Shibaura Institute of Technology
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NISHIBORI Masahiro
Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceu
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MORI Shuji
Department of Bacteriology, Fukushima Medical College
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Takahashi Hideo
Department Of Pharmacology University Of Okayama Graduate School Of Medicine Dentistry And Pharmaceu
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Mori Shuji
Department Of Pharmacology Okayama University Graduate School Of Medicine And Dentistry
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Mori Shuji
Department Of Bacteriology Fukushima Medical College
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Takahashi H
Department Of Pharmacology Okayama University Graduate School Of Medicine And Dentistry
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Mori S
Department Of Pharmacology Okayama University Graduate School Of Medicine And Dentistry
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Nishibori M
Department Of Pharmacology University Of Okayama Graduate School Of Medicine Dentistry And Pharmaceu
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Takahashi Hideo
Department Of Biochemistry School Of Medicine Nihon University
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Takahashi Hideo
Department Of Anatomy Dokkyo Medical University School Of Medicine
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Nishibori Masahiro
Department Of Pharmacology Okayama University Graduate School Of Medicine And Dentistry
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