Effect of Antibodies Against Intercellular Adhesion Molecule-1, B7, and CD40 on Interleukin-18-Treated Human Mixed Lymphocyte Reaction
スポンサーリンク
概要
- 論文の詳細を見る
The interleukin (IL)-18 level in plasma is elevated during the acute rejection after organ transplantation. IL-18 elicits adhesion molecule expression as well as interferon-γ/IL-12 production and T-cell proliferation in the human mixed lymphocyte reaction, an in vitro model of acute rejection. We examined whether antibodies (Abs) against intercellular adhesion molecule (ICAM)-1, B7, CD40, and CD40, ligand (CD40L) affect the cytokine production and T-cell proliferation. Anti-ICAM-1 and B7 Abs suppressed the cytokine production, while all Abs inhibited T-cell proliferation. ICAM-1 and B7 as well as CD40 may play different roles in the acute rejection.
- 社団法人 日本薬理学会の論文
著者
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TAKAHASHI Hideo
Department of Electronics Engineering, Faculty of Engineering, Shibaura Institute of Technology
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Tanosaki R
Division Of Hematology And Hematopoietic Stem Cell Transplantation National Cancer Center Hospital
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NISHIBORI Masahiro
Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceu
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Tamura Ryuji
Department Of Gastroenterological Surgery And Transplant Okayama University Graduate School Of Medic
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Ryuji Tamura
Department Of Materials Science And Technology Science University Of Tokyo
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Yagi Takahito
Department Of Gastroenterological Surgery Transplant And Surgical Oncology Okayama University Gradua
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MORI Shuji
Department of Bacteriology, Fukushima Medical College
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Isozaki Hiroshi
Department Of Gastroenterological Surgery Okayama University Graduate School Of Medicine Dentistry A
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Iwagaki Hiromi
Department Of Gastroenterological Surgery Okayama University Graduate School Of Medicine Dentistry A
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Kohka Takahashi
Department Of Pharmacology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutic
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Tanaka Noriaki
Department Of Gastroenterological Surgery Okayama University Graduate School Of Medicine Dentistry A
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Yoshino Tadashi
Department Of Hematology Okayama Rosai Hospital
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Yagi Takahito
Department Of Gastroenterological Surgery Okayama University Graduate School Of Medicine And Dentist
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Mori Shuji
Department Of Bacteriology Fukushima Medical College
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Tanaka Noriaki
Department Of Cardiovascular Physiology Okayama University
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Tamura Ryuji
Department Of Anesthesiology Faculty Of Medicine University Of Miyazaki
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Takahashi Hideo
Department Of Biochemistry School Of Medicine Nihon University
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Takahashi Hideo
Department Of Anatomy Dokkyo Medical University School Of Medicine
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Yagi Takahito
Department Of Biotechnology Tokyo University Of Agriculture And Technology
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Nishibori Masahiro
Department Of Pharmacology Okayama University Graduate School Of Medicine And Dentistry
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Tamura Ryuji
Department Of Anesthesiology And Intensive Care Faculty Of Medicine University Of Miyazaki
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Yoshino Tadashi
Department Of Cytopathology Ayabe City Hospital
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Takahashi Hideo
Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry
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Yoshino Tadashi
Department of Chemical Engineering, Hiroshima University
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Iwagaki Hiromi
Department of Gastroenterological Surgery and Transplant, Okayama University Graduate School of Medicine and Dentistry
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