Characterization and Gene Expression Profiling of Human Mesenchymal Stem Cells
スポンサーリンク
概要
- 論文の詳細を見る
Human bone marrow mesenchymal stem cells (hMSCs), one of the tissue stem cells, have the ability to differentiate into adipocytes, osteoblasts or chondrocytes, leading to the attempt to apply these stem cells to regeneration of bone and cartilage. To analyze characteristics of these cells and explain pluripotency of hMSCs, we analyzed gene expression profiles of hMSC clones by using DNA chips that contain over 10,000 genes per chip. We also analyzed their proliferation rates and cell surface markers. As a result, these hMSC clones showed various proliferation rates indicating that hMSCs contains multiple types of cells in their population. Furthermore, analysis of surface markers, especially analysis of CD34 and CD44 showed that these stem cells are not hematopoietic stem cells but mesenchymal origin. Profiling of gene expression by using DNA chip showed that several genes were specifically expressed in hMSCs, and the highest expression was observed in clone no. 12 showing that this clone possesses unique characters as a MSC applicable to regeneration research and regenerative medicine.
- 硬組織再生生物学会の論文
著者
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長塚 仁
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry & Pharmaceutical
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長塚 仁
岡山大学大学院医歯薬学総合研究科病態機構学講座口腔病理学分野
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長塚 仁
岡山大学 大学院医歯薬学総合研究科消化器腫瘍外科
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長塚 仁
岡山大学大学院医歯学総合研究科口腔病理病態学講座
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TANAKA NORIAKI
Department of Surgery, Okayama University School of Medicine
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NAKANISHI Tohru
Department of Biochemistiy and Molecular Dentistry, Okayama University Graduate School of Medicine a
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Nagatsuka Hitoshi
Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry & Pharmaceutical S
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Setsu Kojun
Laboratories for Structure and Function Research, Faculty of Pharmaceutical science, Tokushima Bunri
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Nakanishi Tohru
Department Of Clinical Diagnosis Shujitsu University School Of Pharmacy
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Mori Hiroki
Department of Plastic and Reconstructive Surgery, Tokyo Medical and Dental University
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Setsu K
Laboratories For Structure And Function Research Faculty Of Pharmaceutical Sciences Tokushima Bunri
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Setsu Kojun
Laboratory For Structure And Function Research Faculty Of Pharmaceutical Sciences Tokushima Bunri Un
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Setsu Kojun
Laboratories For Structure And Function Reaearch Faculty Of Pharmaceutical Sciences Tokushima Bunri
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Kobayashi Naoya
Department of Cardiology, Kinki University School of Medicine
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Mori Hiroki
Department Of Clinical Diagnosis Shujitsu University School Of Pharmacy
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Tanaka Noriaki
Department Of Surgery Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sc
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Nagatsuka Hitoshi
Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry Okayama Universi
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KOSAKA YOSHIKAZU
Department of Surgery, Okayama University Graduate School of Medicine and Dentistry
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Itano Yoshitaro
Department ofAnesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Denti
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Inoues Masahisa
Laboratories for Structure and Function Research, Faculty of Pharmaceutical science, Tokushima Bunri
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Nakanishi Tohru
Department Of Clinical Pharmacy Shujitsu University School Of Pharmacy
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Kobayashi Naoya
Department Of Cardiology Kinki University School Of Medicine
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Kobayashi Naoya
Department Of Surgery Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sc
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Kosaka Yoshikazu
Department Of Surgery Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sc
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Inoues Masahisa
Laboratories For Structure And Function Research Faculty Of Pharmaceutical Science Tokushima Bunri U
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Itano Yoshitaro
Department Ofanesthesiology And Resuscitology Okayama University Graduate School Of Medicine Dentist
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Setsu Kojun
Laboratories For Structure And Function Research Faculty Of Pharmaceutical Science Tokushima Bunri U
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Tanaka Noriaki
Department Of Gastroenterological Surgery Okayama University Graduate School Of Medicine Dentistry A
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Setsu Kojun
Laboratories For Structure And Function Research Faculty Of Pharmaceutical Sciences Tokushima Bunri
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Tanaka Noriaki
Department Of Cardiovascular Physiology Okayama University
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Mori Hiroki
Department Of Applied Chemistry Graduate School Of Engineering Hiroshima University
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Mori Hiroki
Department Of Clinical Pharmacy Shujitsu University School Of Pharmacy
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