The Study of Palatal Cell Proliferation and Apoptosis in Retinoic Acid Induced Mouse Cleft Palate Varied with Different Developmental Stage
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概要
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To determine the mechanisms and patterns of cleft palate induced by varied retinoic acid (RA) in different developmental stages of secondary palate, we detected the cell proliferation and apoptosis of palatal shelves by BrdU and TUNEL labeling on gestation day (GD) 10 and GD12 which RA was exposed, respectively. In GD 10 RA treated group, the percentage of BrdU positive cells of embryonic palatal mesenchyme were lower than control group, while TUNEL expression was higher than control group. No significant difference was detected in GD12 RA treated group and in control group either in embryonic palatal mesenchyme or medial edge epithelium by BrdU and TUNEL labeling. Our data indicated that the mechanisms of RA induced cleft palate in the early developmental stage were the inhibition of proliferation of palatal mesenchymal cells and medial edge epithelium cells, as well as excessive induction of apoptosis.
著者
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長塚 仁
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry & Pharmaceutical
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長塚 仁
岡山大学大学院医歯薬学総合研究科病態機構学講座口腔病理学分野
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長塚 仁
岡山大学 大学院医歯薬学総合研究科消化器腫瘍外科
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長塚 仁
岡山大学大学院医歯学総合研究科口腔病理病態学講座
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Xiao Jing
Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry & Pharmaceutical S
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Nagatsuka Hitoshi
Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry & Pharmaceutical S
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Katase Naoki
Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry & Pharmaceutical S
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Zhu En-xin
Department Of Oral Biology College Of Stomatology Dalian Medical University
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Xiao Jing
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry & Pharmaceutical
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Xiao Jing
Department Of Oral Biology College Of Stomatology Dalian Medical University
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Katase Naoki
Department Of Oral Pathology And Medicine Okayama University Graduate School Of Medicine Dentistry A
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Cong Wei
Department of Oral Biology, College of Stomatology, Dalian Medical University
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Wang Ru
Department of Oral and Maxillofacial Surgery, College of Stomatology, Dalian Medical University
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Wang Bo
Department of Oral and Maxillofacial Surgery, College of Stomatology, Dalian Medical University
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Wang Fu
Department of Oral Biology, College of Stomatology, Dalian Medical University
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Hu Hailong
Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical
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Hu Hailong
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Nagatsuka Hitoshi
Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry Okayama Universi
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Huang Hai-tao
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Haillong Hu
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Xiao Jing
Department Of Oral Pathology College Of Stomatology Dalian Medical University:department Of Oral Pat
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Xiao Jing
Department Of Oral Pathology College Of Stomatology Dalian Medical University:department Of Oral Pat
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Katase Naoki
Departments Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical
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Xiao Jing
Department Of Oral Pathology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okaya
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Wang Ru
Department Of Oral And Maxillofacial Surgery College Of Stomatology Dalian Medical University
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Wang Bo
Department Of Biochemistry Hamamatsu University School Of Medicine
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Cong Wei
Department Of Oral Biology College Of Stomatology Dalian Medical University
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Katase Naoki
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Hu Hailong
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Haillong Hu
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Wang Fu
Department Of Oral Biology College Of Stomatology Dalian Medical University
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Xiao Jing
Department Of Oral Pathology College Of Stomatology Dalian Medical University:department Of Oral Pat
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Wang Bo
Department of Applied Chemistry, Faculty of Engineering, Oita University
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