Effects of Immobilized Recombinant Human BMP-2/Collagen on Cellular Activity of Osteoblast Like Cells(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)

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概要

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• The use of rhBMP-2 to induce ectopic bone formation requires a carrier. Type I atelocollagen, a biomaterial with a porous structure, excellent operational features and biocompatibility, is known to be an effective carrier for rhBMP-2. However, conventionally used lyophilized rhBMP-2/collagen mixture does not necessarily give adequate bone induction effect. In the present study, we examined the effect of immobilizing rhBMP-2 to type I atelocollagen on the cellular activity of ST2 cells. The following results were obtained: (1) rhBMP-2 was effectively immobilized to succinylated type I atelocollagen, indicating the usefulness of succinylated type I atelocollagen in immobilization. (2) Studies of alkaline phosphatase activity confirmed the effectiveness of rhBMP-2 immobilized on succinylated in augmenting cellular activity.

• 硬組織再生生物学会の論文

著者

• 長塚 仁

  Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry & Pharmaceutical

• 長塚 仁

  岡山大学大学院医歯薬学総合研究科病態機構学講座口腔病理学分野

• 長塚 仁

  岡山大学 大学院医歯薬学総合研究科消化器腫瘍外科

• Nagai Noriyuki

  Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Nagatsuka Hitoshi

  Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Department o

• Hidetsugu Tsujigiwa

  Department Of Virology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama Uni

• Tsujigiwa Hidetsugu

  徳島文理大学 薬学部機能形態学

• Tsujigiwa Hidetsugu

  Department Of Oral Pathology And Medicine Graduate School Of Medicine & Dentistry Okayama Univer

• Tan Jun

  Department Of Oral Pathology School Of Dentistry Okayama University

• Gunduz Mehmet

  Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Tujigiwa Hidetugu

  Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry Okayama Universi

• Tsujigiwa Hidetsugu

  Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry. Okayama Univers

• Kanata Katsunori

  Japan Institute For Advanced Dentistry

• Tsujigiwa Hidetsugu

  Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Yamada Masao

  Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Yamada Masao

  Department Of Virology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama Uni

• Tan Jin

  Tairen University

• Tan Jin

  Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S

• Tujigiwa Hidetugu

  Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry. Okayama Univers

• Nagai Noriyuki

  Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S

• Tujigiwa Hidetugu

  Dept. Of Oral Pathology Okayama Univ. Dental School.

• Nagai Noriyuki

  Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S

• Tsujigiwa Hidetsugu

  Department Of Oral Pathology School Of Dentistry Okayama University

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