Study of Amelogenin Gene Expression in Ameloblastoma(1)(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
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概要
- 論文の詳細を見る
Although it has been known that amelogenin gene is expressed in ameloblastoma, the precise expression pattern of X and Y amelogenin genes (AMGX, AMGY) in this tumor has not yet identified. In this study, we analyzed amelogenin gene expression in 19 samples (9 male, 10 female) of oral ameloblastomas by RT-PCR and detect the chromosomal origin of amelogenin mRNA by restriction enzyme digestion of the RT-PCR product. All tumor samples expressed amelogenin mRNA. We could detect increased level of AMGY expression in all male samples, higher than that of AMEX. It is an interesting finding as in normal male tooth development, the expression of AMGY is very much lower than that of AMGX. We postulate that epigenetic change of sex chromosomes may have some correlations with tumorigenesis of ameloblastoma. We also discuss the other possible mechanisms and points for future studies on this the change in expression pattern.
- 硬組織再生生物学会の論文
著者
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長塚 仁
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry & Pharmaceutical
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長塚 仁
岡山大学大学院医歯薬学総合研究科病態機構学講座口腔病理学分野
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長塚 仁
岡山大学 大学院医歯薬学総合研究科消化器腫瘍外科
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Ichihara Satoshi
Japan Institute for Advanced Dentistry
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Nagai Noriyuki
Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Nagatsuka Hitoshi
Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Department o
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Hidetsugu Tsujigiwa
Department Of Virology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama Uni
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Tsujigiwa Hidetsugu
徳島文理大学 薬学部機能形態学
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Tsujigiwa Hidetsugu
Department Of Oral Pathology And Medicine Graduate School Of Medicine & Dentistry Okayama Univer
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Song Han
Department Of Oral Pathology School Of Dentistry Okayama University
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Gunduz Mehmet
Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Tujigiwa Hidetugu
Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry Okayama Universi
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Tsujigiwa Hidetsugu
Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry. Okayama Univers
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Tsujigiwa Hidetsugu
Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Shin Hong-In
Kyunpook National Univ., Dept. of Oral Pathology
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Yamada Masao
Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Yamada Masao
Department Of Virology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama Uni
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Shim Hong
Kyunpook National Univ. Dept. Of Oral Pathology
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Shin Hong-in
Kyunpook National Univ. Dept. Of Oral Pathology
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Tujigiwa Hidetugu
Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry. Okayama Univers
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Nagai Noriyuki
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Tujigiwa Hidetugu
Dept. Of Oral Pathology Okayama Univ. Dental School.
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Han Song
Department Of Oral Pathology School Of Dentistry Okayama University
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Nagai Noriyuki
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Tsujigiwa Hidetsugu
Department Of Oral Pathology School Of Dentistry Okayama University
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