Identification of Caspase-6 as A Candidate Tumor Suppressor Gene at 4q25 in Oral Cancer(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)

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概要

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• We recently reported the frequent deletion of chromosome 4q25 region in oral squamous cell carcinoma and discussed the Caspase-6 as a possible tumor suppressor gene in this region due to its near location to this hot spot. We this time examined the role of Caspase-6 in oral cancers. mRNA expression level, protein localization and gene mutation of Caspase-6 were analyzed. Reverse-transcription-PCR analysis demonstrated decreased expression in 40% and equal expression in 30% of Caspase-6 mRNA of primary tumors as compared with that matched normal samples. cDNA sequencing analysis of Caspase-6 did not reveal any somatic mutation. Caspase-6 protein localization was in similar proportion with its mRNA expression. Failure of Caspase-6 response in tumor samples as compared to normal samples could suggest Caspase-6 as a candidate tumor suppressor gene in a subset of oral cancer.

• 硬組織再生生物学会の論文

著者

• Nagai Noriyuki

  Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Shinnou Yasuo

  Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry Okayama Universi

• Shinno Yasuo

  Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sciences

• Akita Yasuhiru

  Japan Institute For Advanced Dentistry

• Shimizu Kenji

  Department Of Molecular Genetics Graduate School Of Medicine Dentistry And Pharmaceutical Sciences O

• Gunduz Mehmet

  Department Of Otolaryngology Head And Neck Surgery Wakayama Medical University

• Gunduz Mehmet

  Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Shimizu Kenji

  Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Esra Gunduz

  Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S

• Gunduz Esra

  Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S

• Yoshiyama Masahiro

  Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sciences

• Nagai Noriyuki

  Department Of Oral Pathology Okayama University Dental School

• Gunduz Esra

  Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Yasuoka Akira

  Japan Institute for Advanced Dentistry

• Nagai Noriyuki

  Dept. Of Oral Pathology Okayama Univ. Dental School.

• Gunduz Mehmet

  岡山大学大学院医歯学総合研究科病態機構学講座:口腔病理病態学分野

• Gunduz Esra

  Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry Okayama Universi

• Nagai Noriyuki

  Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S

• Nagai Noriyuki

  Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S

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