Initial Calcification of Bone Formation in Ectopic and Osteogenic Tissue Induced by BMP-Collagen Composites(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
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概要
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In this study, the initial osteoinductive capacity and bone forming patterns induced by BMP were studied using routine histology and electron microscopy. The pattern of initial calcification is different in induced bone formation at heterotopic sites. Three experiments were conducted; BMP and atelocollagen complexes were implanted into subcutaneous and subperiosteal tissues of rats. Initial calcification multi potentially started in matrix vesicles of osteoid tissue as well as in carrier collagen fibers. Bone formation occurs either via preexisting cartilage or directly according to the geometry of carriers used and the micro environmental conditions. In this study we conducted an ultra structural analysis of subcutaneously implanted both bovine extracted BMP and rhBMP with collagen carriers and subperiosteally implanted rhBMP-collagen composites in rats to understand the effects of carrier and environmental conditions on bone formation.
著者
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Nagai Noriyuki
Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry & Pharmaceutical S
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KINUTA Yoshihiro
Department of Oral Pathology, School of Dentistry, Okayama University
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Sugiyama Koji
Japan Institute For Advanced Dentistry
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Gunduz Mehmet
Department Of Otolaryngology Head And Neck Surgery Wakayama Medical University
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Ali Mahmoud
Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical
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Nagai Noriyuki
Department Of Oral Pathology And Medicine Dental School Okayama University
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Kinuta Yoshihiro
Department Of Occlusal And Oral Functional Rehabilitation Graduate School Of Medicine Dentistry And
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Gunduz Mehmet
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Tan Jin
Department Of Molecular Medicine Faculty Of Medicine University Of Malaya
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Huang Bing-zhen
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Ali Mahmoud
College Of Dentistry Jordan University:department Of Oral Pathology And Medicine Graduate School Of
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Ali Mahmoud
Department Of Oral Pathology And Medicine Dentistry And Pharmaceutical Sciences Okayama University
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Kinuta Yoshihiro
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Ali Mahmoud
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Tan Jin
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Tamagawa Katsuki
Japan Institute For Advanced Dentistry
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Nagai Noriyuki
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Nagai Noriyuki
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Tan Jin
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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