Long-term Observations of Heterotopic Bone Formation Induced by rhBMP-2 and IBM Composites
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概要
- 論文の詳細を見る
We examined the long-term results of rhBMP-2 (recombinant human bone morphogenetic protein-2), delivered in IBM (insoluble bone matrix) particle implante, on heterotopic bone formation in rats. The purpose was to evaluate the IBM delivery system as an effective carrier for possible finding an effective carrier which can be applied clinically from this clue. Chondroblast cells couforming to the shape of lacunae with the basophilic matrix were observed at one and two weeks after implantation. The chondroid tissue was partially absorbed at two weeks after implantation. Bone formation and remodelling were noticed from two weeks. Both endochondral and intramembranous ossification were observed, and the former was predominant at two weeks. A bone m arrow-like structure was obrerved at three weeks and a fatten marrow was found from four weeks. New bone formation and absorption were not active from seven weeks after implantation. IBM particles were covered by new bone in a stable state. By the end of nine weeks mature bone tissue was still present. Thus. rhBMP-2 and IBM composites have a high osteoinductive capability, and the newly formed bone was relatively stable for a long time. This result indicates that IBM provides an excellent delivery system in the early period of the rhBMP-2 induced bone formation. After remodeling of the new bone, IBM seems to turn into a part of the bone matrix.
- 硬組織再生生物学会の論文
著者
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Nagatsuka Hitoshi
Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry & Pharmaceutical S
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Nagai Noriyuki
Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry & Pharmaceutical S
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Inoue Masahisa
Laboratories For Structure And Function Research Faculty Of Pharmaceutical Sciences Tokushima Bunri
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Inoue Masahisa
徳島文理大学 薬学部機能形態学
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Tan Jun
Department Of Oral Pathology College Of Stomatology Dalian Medical University
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Tan Jun
Department Of Oral Pathology School Of Dentistry Okayama University
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Song Han
Department Of Oral Pathology School Of Dentistry Okayama University
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Inoue Masahisa
Department of Oral Pathology, School of Dentistry, Okayama University
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Nagatsuka Hitoshi
Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry Okayama Universi
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Nagai Noriyuki
Department Of Oral Pathology And Medicine Dental School Okayama University
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HAN Song
Department of Oral Pathology, School of Dentistry, Okayama University
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CHU Hong
Department of Oral Pathology, School of Dentistry, Okayama University
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Tan Jun
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Chu Hong
Department Of Oral Pathology School Of Dentistry Okayama University
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Shim Hong
Kyunpook National Univ. Dept. Of Oral Pathology
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Inoue Masahisa
Department Of Oral Pathology And Medicine Okayama University Graduate School Of Medicine Dentistry A
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Tan Jin
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Han Song
Department Of Oral Pathology School Of Dentistry Okayama University
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Inoue Masahisa
Department Of Biomaterials And Biomimetics College Of Dentistry New York University
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Inoue Masahisa
Laboratories For Structure And Function Research Faculty Of Pharmaceutical Sciences Tokushima Bunri
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Han Song
Department of Internal Medicine, Gachon University Gil Medical Center, Graduate School of Medicine, Gachon University
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