Histological and Morphometrical Study of Bone Formation in Rat Subcutaneous Tissue by BMP-Collagen Particles
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概要
- 論文の詳細を見る
Two types of collagen particles (CP), each combined with bovine bone morphogenetic protein (S-200 BMP) were implanted in the rat dorsal subcutaneous tissues. The osteoinductive capacity and bone forming patterns were observed in histological and morphometrical studies. The carriers were wet and dry collagen particles (CPw, CPd). CPw was round shaped and CPd was star shaped. The carriers alone was implanted as a control. Each composite and its surrounding tissues were removed 1, 2 and 3 weeks later and were studied by routine histology and Weibel's morphometry. S-2OO BMP・CPd induced bone tissues in a process that resembled an endochondral ossification mode. This system also induced bone formation through a direct ossification mode. On the other hand, S-200 BMP-CPw induced bone formation in a process that resembled intramembranous ossification. S-200 BMP-collagen particle composites induced immature mesenchymal cells to become either osteogenetic or chondrogenetic cells or both, depending on the shape of the carrier that affected the microenvironment during cell differentiation.
- 硬組織再生生物学会の論文
著者
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Nagai Noriyuki
Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry & Pharmaceutical S
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MURATA Masaru
Department of Oral Maxillo-facial Surgery, School of Dentistry, Health Sciences University of Hokkai
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Murata Masaru
北海道医療大学 歯 第2口腔外科
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Murata M
Okayama Univ. Okayama Jpn
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Liliana Missana
Department Of Oral Pathology School Of Dentistry Okayama University
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Takagi Tohru
Department Of Oral Pathology And Medicine Okayama University Graduate School Of Medicine Dentistry A
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Takagi Tohru
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Konouchi Hironobu
Department of Oral pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical
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Konouchi Hironobu
Japan Institute For Advanced Dentistry:okayama University Graduate School Of Medicine Dentistry And
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Konouchi Hironobu
Department Of Oral And Maxillofacial Radiology Okayama University Graduate School Of Medicine And De
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Konouchi Hironobu
Dept. Of Oral Pathology Okayama Univ. Dental School.
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Nagai Noriyuki
Department Of Oral Pathology And Medicine Dental School Okayama University
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Murata Masaru
Department Of Oral Pathology School Of Dentistry Okayama University
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Murata Masaru
Department Of Oral Maxillofacial Surgery School Of Dentistry Health Sciences University Of Hokkaido
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NOSAKA Yukio
Japan Institute for Advanced Dentistry
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TAKAHASHI Atsushi
Japan Institute for Advanced Dentistry
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NOSAKA Takashi
Japan Institute for Advanced Dentistry
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ONOUE Yuhei
Japan Institute for Advanced Dentistry
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YASUDA Kouji
Japan Institute for Advanced Dentistry
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Murata Masaru
Department Of Architecture And Building Engineering School Of Engineering
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Nagai Noriyuki
Dept. Of Oral Pathology Okayama Univ. Dental School.
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Nosaka Yukio
Department Of Oral Pathology Okayama University Dental School
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Kou Hirokuni
Japan Institute For Advanced Dentistry:okayama University Graduate School Of Medicine Dentistry And
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Takagi Tohru
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Takagi Tohru
Department Of Biochemistry Faculty Of Dentistry Tokyo Medical And Dental University
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Murata Masaru
2nd Department Of Oral Surgery School Of Dentistry Health Sciences University Of Hokkaido
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Murata Masaru
Department Of Oral And Maxillofacial Surgery School Of Dentistry Health Sciences University Of Hokka
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Takagi Tohru
Department Of Oral Pathology And Medicine Okayama University Graduate School Of Medicine Dentistry A
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Nagai Noriyuki
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Takagi Tohru
Department Of Virology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama Uni
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Takagi Tohru
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Murata Masaru
Department Of Oral And Maxillofacial Surgery School Of Dentistry Health Sciences University Of Hokka
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Kou Hirokuni
Japan Institute For Advanced Dentistry:okayama University Graduate School Of Medicine Dentistry And
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Konouchi Hironobu
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Takagi Tohru
Department Of Virology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama Uni
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Takagi Tohru
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Nosaka Yukio
Japan Institute For Advanced Dentistry:department Of Oral Pathology School Of Dentistry Okayama Univ
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