In Vivo Effect of Fluoride-substituted Apatite on Rat Bone
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概要
- 論文の詳細を見る
Different types of calcium phosphate compounds are commercially available for medical and dental applications as bone substitute materials. Biological apatites contain several kinds of minor elements such as carbonate (CO_3), magnesium (Mg), and fluoride (F) in enamel, dentin, and bone. It has been shown that F ion and F-substituted apatite promoted osteoblast proliferation and inhibited osteoclast cell activity. The purpose of this study was to investigate the in vivo rat tibia activity on F-substituted apatite (FAp). Apatites of unsintered calcium deficient apatite (CDA), and FAps, with low, medium, and high F concentrations, were implanted in rat tibia for 1 and 2 weeks. Implanted tissues were embedded in paraffin blocks, stained with hematoxylin-eosin and histomorphometrically observed. Results showed that low F concentration induced better and faster new bone formation in vivo compared to CDA. Therefore the results suggested that F as a minor element in bone rendered a suitable effect on bone formation in vivo.
- 日本歯科理工学会の論文
著者
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LEGEROS Racquel
ニューヨーク大学
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Yamamoto Toshio
Department Of Oral Function And Anatomy In Okayama University Graduate School Of Medicine Dentistry
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Nagatsuka Hitoshi
Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry & Pharmaceutical S
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Nagai Noriyuki
Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry & Pharmaceutical S
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Inoue Masahisa
Laboratories for Structure and Function Research, Faculty of Pharmaceutical Sciences, Tokushima Bunr
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Inoue Miho
Department of Biomaterials and Biomimetics, College of Dentistry, New York University
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Inoue Masahisa
Laboratories For Structure And Function Research Faculty Of Pharmaceutical Sciences Tokushima Bunri
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Inoue Masahisa
徳島文理大学 薬学部機能形態学
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Hidetsugu Tsujigiwa
Department Of Virology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama Uni
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Tsujigiwa Hidetsugu
徳島文理大学 薬学部機能形態学
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Tsujigiwa Hidetsugu
Department Of Oral Pathology And Medicine Graduate School Of Medicine & Dentistry Okayama Univer
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Legeros Racquel
Department Of Biomaterials And Biomimetics New York University College Of Dentistry
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Legeros Racquel
Department Of Biomaterials And Biomimetics College Of Dentistry New York University
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Legeros Racquel
日本大学松戸歯学部 組織・発生・解剖学講座
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Nagatsuka Hitoshi
Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry Okayama Universi
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Nagai Noriyuki
Department Of Oral Pathology And Medicine Dental School Okayama University
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Tujigiwa Hidetugu
Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry Okayama Universi
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Tsujigiwa Hidetsugu
Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry. Okayama Univers
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Tujigiwa Hidetugu
Department Of Oral Pathology And Medicine Graduate School Of Medicine And Dentistry. Okayama Univers
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Nagai Noriyuki
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Tujigiwa Hidetugu
Dept. Of Oral Pathology Okayama Univ. Dental School.
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Nagai Noriyuki
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Inoue Masahisa
Department Of Biomaterials And Biomimetics College Of Dentistry New York University
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Yamamoto Toshio
Department Of Oral Morphology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okay
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Yamamoto Toshio
Department Of Agricultural Chemistry Yamagata University
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Inoue Masahisa
Laboratories For Structure And Function Research Faculty Of Pharmaceutical Sciences Tokushima Bunri
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Tsujigiwa Hidetsugu
Department Of Oral Pathology School Of Dentistry Okayama University
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