Immunohistochemical Demonstration of Adenosine Deaminase (ADA 1) in Human Tissues

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概要

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• The localization of adenosine deaminase (ADA 1) in human tissues was investigated by an immunohistochemical method. Tissues were taken from cadavers, fixed with 4% paraformaldehyde-PBS, and embedded in paraffin, and then examined following immunoperoxidase staining using a rabbit polyclonal antibody against keyhole limpet hemocyanin (KLH)-peptide conjugate (Ser-Phe-Leu-Pro-Glu-Asp-Glu-Lys-Arg-Glu-Leu-Leu) constructed from a human adenosine deaminase cDNA sequence. Immuno-histochemical analysis demonstrated that ADA 1 was distributed in various human tissues, with intense reactivity observed in surface epithelia of the esophagus, stomach, small intestine, renal tubules, glandular cells of the small intestine, endothelial lining cells of the liver, and alveoli of the lung. Moderate reactivity was observed in the glomerulus cells of the kidney, epithelia and glandular cells of the large intestine, and hepatic parenchymal cells. This ubiquitous but cell-specific localization suggests that ADA 1 plays an important role in selected cells through the degradation of adenosine, a pharmacological active nucleoside.

• 日本組織細胞化学会の論文

著者

• YAMAMOTO Tetsuya

  Division of Chemistry, Graduate School of Science, Hokkaido University

• Yamamoto Toshio

  Department Of Oral Function And Anatomy In Okayama University Graduate School Of Medicine Dentistry

• Yamamoto Toshio

  岡山大学 医歯薬学総合研究科口腔形態学

• Moriwaki Yuji

  Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine

• Ka Tsuneyoshi

  Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine

• Takahashi Sumio

  Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine

• Tsutsumi Zenta

  Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine

• Moriwaki Yuji

  兵庫医科大学 内科学内分泌･代謝科

• Moriwaki Yuji

  Third Department Of Internal Medicine Hyogo College Of Medicine

• Ka Tsuneyoshi

  Division Of Endocrinology And Metabolism Department Of Internal Medicine Hyogo College Of Medicine

• Takahashi Sumio

  兵庫医科大学 内科学内分泌･代謝科

• Tsutsumi Zenta

  兵庫医科大学 内科学内分泌･代謝科

• Tsutsumi Zenta

  Division Of Endocrinology And Metabolism Department Of Internal Medicine Hyogo College Of Medicine

• Moriwaki Yuji

  Division Of Endocrinology And Metabolism Department Of Internal Medicine Hyogo College Of Medicine

• Yamamoto T

  Division Of Hepatobiliary And Pancreatic Medicine Department Of Internal Medicine Hyogo College Of M

• HADA TOSHIKAZU

  Division of Hepatobiliary and Pancreatic Medicine, Department of Internal Medicine, Hyogo College of

• Yamamoto Tetsuya

  Division Of Hepatobiliary And Pancreatic Medicine Department Of Internal Medicine Hyogo College Of M

• Takahashi Sumio

  Division Of Endocrinology And Metabolism Department Of Internal Medicine Hyogo College Of Medicine

• Yamamoto Takayuki

  Department Of Oral Pathology Kanagawa Dental College

• Hada Toshikazu

  Division Of Hepatobiliary And Pancreatic Medicine Department Of Internal Medicine Hyogo College Of M

• Yamamoto Tomomi

  Dept. Of Histology And Cell Biology:dept. Of Otolaryngology

• Yamamoto-fukuda Tomomi

  Histology And Cell Biology:otolaryngology Nagasaki University School Of Medicine

• Hada Toshikazu

  Department Of Molecular Medicine Osaka University Graduate School Of Medicine

• Takahashi S

  Division Of Endocrinology And Metabolism Department Of Internal Medicine Hyogo College Of Medicine

• Yamamoto Tetsuya

  Division Of Hepatobiliary And Pancreatic Medicine Department Of Internal Medicine Hyogo College Of M

• Yamamoto Tetsuo

  Division Of Hepatobiliary And Pancreatic Medicine Department Of Internal Medicine Hyogo College Of M

• Yamamoto Tetsuya

  Division Of Chemistry Graduate School Of Science Hokkaido University

• Hada Toshikazu

  Division Of Hepatobiliary And Pancreatic Diseases Department Of Internal Medicine Hyogo College Of Medicine

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