The Role of Metallothionein in Hard Tissue(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
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概要
- 論文の詳細を見る
We studied the metallothionein (MT) induction by cadmium (Cd) in the dental pulp and bone in rats. In order to clarity the cell response to Cd in the hard tissue, the isoform-specific expression of MT mRNAs (MT-I and MT-II) was examined by reverse transcriptase-polymerase chain reaction (RT-PCR) method, and the localization of MT was confirmed by immunohistochemical studies. Both MT-I and MT-II mRNA levels were increased within 3 hours by Cd administration in both the dental pulp and bone. In the dental pulp, MT protein was localized in the specific cell type of odontoblasts (secretory odontoblasts and resting odontoblasts). In the bone, MT-positive cells were time-dependently increased, and the positive cells were mainly localized in osteocytes. The cell-specific induction of MT may be associated with Cd accumulation and Cd-induced the hard tissue injury in vivo.
- 硬組織再生生物学会の論文
著者
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Yamamoto Toshio
Department Of Oral Function And Anatomy In Okayama University Graduate School Of Medicine Dentistry
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Aoki Chiharu
Department Of Dental Pharmacology
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Onodera Kenji
Department Of Dental Pharmacology
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Sogawa N
Department Of Dental Pharmacology
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Sogawa Norio
Department Of Dental Pharmacology Okayama University Graduate School Of Medicine And Dentistry
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Sogawa Chiharu
Department Of Dental Pharmacology Okayama University Graduate School Of Medicine Dentistry And Pharm
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FURUTA Hiroaki
Department of Dental Pharmacology, Okayama University Dental School
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Kitayama Shigeo
Department Of Dental Pharmacology
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Furuta H
Department Of Dental Pharmacology
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Oda Nariaki
Department of Dental Pharmacology
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Yamamoto Toshio
Department Of Oral Morphology Okayama University Graduate School Of Medicine Dentistry And Pharmaceu
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Yamamoto Toshio
Department Of Agricultural Chemistry Yamagata University
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Sogawa Norio
Department Of Dental Pharmacology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences
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Furuta Hiroaki
Department Of Dental Pharmacology
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ONODERA Kenji
Department of Chemical Pharmacology, Tohoku College of Pharmacy
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Sogawa Norio
Department of Dental Pharmacology
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