Antinociceptive Effect of Vitamin K_2 (Menatetrenone) in Diabetic Mice

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概要

• 論文の詳細を見る

• The antinociceptive effect of vitamin K2 (menatetrenone) in diabetic mice was examined using a tail-pressure test. Intraperitoneal injection of menatetrenone (10 - 100 mg/kg) produced a dose-dependent increase in the nociceptive threshold in diabetic mice. There was no significant difference between non-diabetic and diabetic mice in the menatetrenone-induced changes in the nociceptive threshold. The results suggest the therapeutical usefulness of menatetrenone for treating painful diabetic neuropathy and osteoporosis.

• 社団法人 日本薬理学会の論文
• 2001-03-01

著者

• ONODERA Kenji

  Department of Pharmacology, Tohoku University School of Dentistry

• KAMEI Junzo

  Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University

• Onodera K

  Department Of Dental Pharmacology Okayama University Graduate School Of Medicine And Dentistry

• Onodera Kenji

  Department Of Dental Pharmacology

• Kamei Junzo

  Department Of Pathophysilology & Therapeutics Faculty Of Pharmaceutical Sciences Hoshi Universit

• ZUSHIDA Ko

  Department of Pathophysiology & Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University

• Zushida K

  Department Of Pathophysiology & Therapeutics Faculty Of Pharmaceutical Sciences Hoshi University

• Kamei Junzo

  星薬科大学 薬学部薬物治療学

• ONODERA Kenji

  Department of Chemical Pharmacology, Tohoku College of Pharmacy

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