Modification of the Expression of Naloxone-Precipitated Withdrawal Signs in Morphine-Dependent Mice by Diabetes : Possible Involvement of Protein Kinase C
スポンサーリンク
概要
- 論文の詳細を見る
The involvement of cyclic AMP-dependent protein kinase (PKA) and protein kinase C (PKC) in the modulation of naloxone-precipitated withdrawal jumping in morphine-dependent mice by diabetes was examined. Naloxone-precipitated withdrawal jumps were significantly less in morphine-dependent diabetic mice than in morphine-dependent non-diabetic mice. I.c.v. pretreatment with either calphostin C, a PKC inhibitor, or KT-5720, a PKA inhibitor, attenuated naloxone-precipitated withdrawal jumps in morphine-dependent non-diabetic mice. However, naloxone-precipitated withdrawal jumps in morphinedependent diabetic mice were not attenuated by i.c.v. pretreatment with either calphostin C or KT5720. Moreover, i.c.v. pretreatment with phorbol-12, 13-dibutyrate (PDBu), a PKC activator, attenuated naloxone-precipitated withdrawal jumps in morphine-dependent non-diabetic mice, but not in morphine-depend- ent diabetic mice. The noradrenaline (NA) turnover in the frontal cortex in morphine-dependent non-dia- betic mice, but not in morphine-dependent diabetic mice, was significantly increased 5 min after adminis- tration of naloxone. Naloxone-induced enhancement of NA turnover in morphine-dependent non-diabetic mice, but not in morphine-dependent diabetic mice, was blocked by i.c.v. pretreatment with either calphostin C or KT5720 1 hr before naloxone challenge and blocked by PDBu 1 hr before the last injection of morphine. These results suggest that the co-activation of PKC and PKA is needed to elicit naloxone-precipitated withdrawal jumps and enhancement of turnover rate of NA in the frontal cortex in morphine-dependent non-diabetic mice. Furthermore, the attenuation of naloxone-precipitated withdrawal jumps in morphine-dependent diabetic mice may be due, in part, to the desensitization of μ-opioid receptors by the activation of PKC.
- 社団法人 日本薬理学会の論文
- 1999-03-01
著者
-
KAMEI Junzo
Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University
-
Ohsawa Masahiro
Department Of Pathophysiology And Therapeutics School Of Pharmacy And Pharmaceutical Sciences Hoshi
-
Ohsawa Masahiro
Department Of Endodontics And Operative Dentistry Nagasaki University School Of Dentistry
-
Ohsawa Masahiro
Department Of Pathophysiology & Therapeutics Faculty Of Pharmaceutical Sciences Hoshi University
-
Kamei Junzo
Department Of Pathophysilology & Therapeutics Faculty Of Pharmaceutical Sciences Hoshi Universit
-
Kamei Junzo
Department Of Pathophysiology & Therapeutics Faculty Of Pharmaceutical Sciences Hoshi University
関連論文
- Effects of Chronic Administration of Zonisamide, an Antiepileptic Drug, on Bone Mineral Density and Their Prevention With Alfacalcidol in Growing Rats
- Gene Expression Profiling Reveals Complex Changes in the Olfactory Bulbectomy Model of Depression After Chronic Treatment With Antidepressants
- Effects of Methylphenidate on the Hyperemotional Behavior in Olfactory Bulbectomized Mice by Using the Hole-Board Test
- Changes in Emotional Behavior of Mice in the Hole-Board Test After Olfactory Bulbectomy
- Effects of First- and Second-Generation Histamine-H_1-Receptor Antagonists on the Pentobarbital-Induced Loss of the Righting Reflex in Streptozotocin-Induced Diabetic Mice
- Antinociceptive Mechanism of Gosha-jinki-gan in StreptozotocinInduced Diabetic Animals: Role of Nitric Oxide in the Periphery
- Antinociceptive Effect of Gosha-jinki-gan, a Kampo Medicine, in Streptozotocin-Induced Diabetic Mice
- Effect of Gosha-jinki-gan, a Kampo Medicine, on Enhanced Platelet Aggregation in Streptozotocin-Induced Diabetic Rats
- Potential Anxiolytic and Antidepressant-Like Activities of SNC80, a Selective δ-Opioid Agonist, in Behavioral Models in Rodents
- TRK-820, a Selective к-Opioid Agonist, Produces Potent Antinociception in Cynomolgus Monkeys
- Pitavastatin Inhibits Vascular Smooth Muscle Cell Proliferation by Inactivating Extracellular Signal-Regulated Kinases 1/2
- Implication of the Descending Dynorphinergic Neuron Projecting to the Spinal Cord in the (+)-Matrine-and (+)-Allomatrine-Induced Antinociceptive Effects(Medicinal Chemistry)
- Modification of the Effects of Benzodiazepines on the Exploratory Behaviors of Mice on a Hole-Board by Diabetes
- Hypoglycemic Effects of Multiflorine Derivatives in Normal Mice(Medicinal Chemistry)
- The Hypoglycemic Effect of (7R^*, 9aS^*)-7-Phenyl-octahydroquinolizin-2-one in Mice
- P-532 Structure-Antitussive Activity Relationships of Naltrindole Derivatives : Discovery of Novel and Potent Antitussive Agents
- Effects of Serotonergic Anxiolytics on the Freezing Behavior in the Elevated Open-Platform Test in Mice
- Antinociceptive Effect of Vitamin K_2 (Menatetrenone) in Diabetic Mice
- Modification of κ-Opioid Receptor Agonist-Induced Antinociception by Diabetes in the Mouse Brain and Spinal Cord
- Potentiation of the Antidepressant-Like Effect of Fluoxetine by Aripiprazole in the Mouse Tail Suspension Test
- Effects of Double-enkephalin (Biphalin), an Enkephalin Analogue, on Respiration and the Cough Reflex in Rats
- Effect of Diabetes on the Morphine-Induced Inhibition of Gastrointestinal Tranist
- Effect of Mexiletine on Thermal Allodynia and Hyperalgesia in Diabetic Mice
- Effects of T-82, a New Quinoline Derivative, on Cholinesterase Activity and Extracellular Acetylcholine Conventration in Rat Brain
- Effect of Mexiletine on Fenvalerate-Induced Nociceptive Response in Diabetic Mice
- Modification of the Expression of Naloxone-Precipitated Withdrawal Signs in Morphine-Dependent Mice by Diabetes : Possible Involvement of Protein Kinase C
- Inhaled Pinacidil, an ATP-Sensitive K+ Channel Opener, and Moguisteine Have Potent Antitussive Effects in Guinea Pig
- Dimensional Changes of MOD Mold Cavity Corresponding to the Degree of Setting Expansion
- Effects of Streptozotocin-Induced Diabetes on Place Conditioning Action of Cocaine in Mice
- Nociception and Allodynia/Hyperalgesia Induced by Intrathecal Administration of Fenvalerate
- EFFECTS OF 8-(2-FLUOROETHYL)-3α-HYDROXY-lαH, 5αH-TROPANIUMBROMIDE BENZILATE (Ba598Br) ON ALLERGY AND DRUG-INDUCED ASTHMAS
- ANALYSIS OF EFFERENT DISCHARGES OF THE PHRENIC NERVE DURING THE COUGH REFLEX
- Different effects of smoke from heavy and light cigarettes on the induction of bronchial smooth muscle hyperresponsiveness in rats
- Nucleus Accumbens and Dopamine-Mediated Turning Behavior of the Rat: Role of Accumbal Non-dopaminergic Receptors
- Inhibitory Reflex during Bronchoconstrictions Induced by Histamine and Ascaris Suum Antigen.
- Involvement of central serotonergic mechanisms in the cough reflex.
- Potential Anxiolytic and Antidepressant-Like Activities of SNC80, a Selective .DELTA.-Opioid Agonist, in Behavioral Models in Rodents
- Analysis of the vagal reflex tracheal constriction in the dog.
- Changes in Emotional Behavior of Mice in the Hole-Board Test After Olfactory Bulbectomy
- Antitussive effect of RU-20201 - Central and peripheral actions.
- Effects of methysergide on the cough reflex.
- Effects of L-tryptophan on the development of tolerance to the antitussive effects of dihydrocodeine.
- Effects of Morphine on Responses of Nociceptive Ventrobasal Thalamic Neurons in Diabetic Rats.
- Blockade of .DELTA.-Opioid Receptors Prevents Morphine-Induced Place Preference in Mice.
- Inhibitory modulation on the reflex tracheal constriction induced by afferent vagal stimulation.
- Nucleus Accumbens and Dopamine-Mediated Turning Behavior of the Rat : Role of Accumbal Non-dopaminergic Receptors