Gene Expression Profiling Reveals Complex Changes in the Olfactory Bulbectomy Model of Depression After Chronic Treatment With Antidepressants
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概要
- 論文の詳細を見る
We investigated the effects of antidepressants on the gene expression profile and behavior of olfactory-bulbectomized (OBX) rats. Removal of the main olfactory bulbs in rats alters neuronal function in brain areas involved in emotional regulation, resulting in maladaptive behavioral patterns similar to the symptoms of patients with depression. Previously, we found that OBX-induced behavioral and neuronal abnormalities were completely rescued by chronic treatment with SNC80, an opioid delta agonist, as well as with classical monoaminergic antidepressants. Thus, to determine the basis for this effect, we analyzed gene expression in OBX rat frontal cortex using a GeneChip® rat Genome oligonucleotide array after imipramine or SNC80 treatment. We found that imipramine and SNC80 induced the following systematic changes in OBX rats: zinc ion binding; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; protein serine/threonine kinase activity; N-acetyltransferase activity; protein modification process; regulation of cellular process; and regulation of neurotransmitter levels. Defining the roles of candidate neuronal systems in antidepressant-induced neural changes are likely to transform the course of research on the biological basis of mood disorders.
- 社団法人 日本薬理学会の論文
- 2008-11-20
著者
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Maruyama Yoshiaki
Department of Health Promotion, Saitama Medical Center, Saitama Medical University
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SAITOH Akiyoshi
Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hosh
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KAMEI Junzo
Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University
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Yamada Mitsuhiko
Department of Molecular Pharmacology, Shinshu University School of Medicine
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Saitoh Akiyoshi
Department Of Pathophysiology & Therapeutics School Of Pharmacy And Pharmaceutical Sciences Hosh
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TAKAHASHI Kou
Department of Psychogeriatrics, National Institute of Mental Health, National Center of Neurology an
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YAMADA Misa
Department of Psychogeriatrics, National Institute of Mental Health, National Center of Neurology an
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HIROSE Noritaka
Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hosh
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Hirose Noritaka
Department Of Pathophysiology And Therapeutics School Of Pharmacy And Pharmaceutical Sciences Hoshi
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Maruyama Yoshiaki
Department Of Health Promotion Saitama Medical Center Saitama Medical University
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Maruyama Yoshiaki
Department Of Psychogeriatrics National Institute Of Mental Health National Center Of Neurology And
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Yamada Mitsuhiko
Department Of Psychogeriatrics National Institute Of Mental Health National Center Of Neurology And
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Yamada Misa
Department Of Psychogeriatrics National Institute Of Mental Health National Center Of Neurology And
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Kamei J
Department Of Pathophysiology And Therapeutics Faculty Of Pharmaceutical Sciences Hoshi University
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Kamei Junzo
国立精神･神経センター精神保健研究所 老人精神保健部
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Kamei Junzo
Department Of Pathophysilology & Therapeutics Faculty Of Pharmaceutical Sciences Hoshi Universit
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Takahashi Kou
Department Of Psychogeriatrics National Institute Of Mental Health National Center Of Neurology And
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Takahashi Kou
Department Of Applied And Environmental Chemistry Kitami Institute Of Technology
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Yamada Mitsuhiko
Department Of Molecular Pharmacology Shinshu University School Of Medicine
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Saitoh A
Department Of Pathophysiology And Therapeutics School Of Pharmacy And Pharmaceutical Sciences Hoshi
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Saitoh Akiyoshi
Department of Neuropsychopharmacology, National Institute of Mental Health National Center of Neurology and Psychiatry, Japan
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Hirose Noritaka
Department of Pathophysiology & Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Japan
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