Hypoglycemic Effects of Multiflorine Derivatives in Normal Mice(Medicinal Chemistry)
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概要
- 論文の詳細を見る
(-)-Multiflorine isolated from leguminous plants produces a hypoglycemic effect when administered to mice with streptozotocin-induced diabetes. (-)-Multiflorine has an enaminone-type conjugation on the A ring, which is unusual in lupine alkaloids. Proceeding on the assumption that the A-B ring is responsible for the hypoglycemic effect, several compounds bearing the quinolizidin-2-one ring system were synthesized, and their hypoglycemic effects were examined. In addition, tricyclic compounds bearing 4-pyridone were synthesized, and their hypoglycemic effects were examined. The hypoglycemic effect of a 4-pyridone-type compound was similar to that of (-)-multiflorine as measured by oral glucose tolerance testing in normal mice. No hypoglycemic effect of a 4-piperidone-type compound was observed. These results indicate that compounds possessing double bond(s) in the A ring of multiflorine may be lead compounds for a new type of diabetes drug.
- 公益社団法人日本薬学会の論文
- 2006-10-01
著者
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Kubo H
New Product Research Laboratories Ii Daiichi Pharmaceutical Company Ltd.
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KAMEI Junzo
Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University
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KUBO Hajime
Faculty of Medicinal Chemistry; Hoshi University
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KUBO Hajime
Institute of Medicinal Chemistry, Hoshi University
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HIGASHIYAMA Kimio
Institute of Medicinal Chemistry, Hoshi University
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Kamei J
Department Of Pathophysiology And Therapeutics Faculty Of Pharmaceutical Sciences Hoshi University
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Kamei Junzo
国立精神・神経センター精神保健研究所 老人精神保健部
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Kamei Junzo
Department Of Pathophysilology & Therapeutics Faculty Of Pharmaceutical Sciences Hoshi Universit
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INOUE Mai
Institute of Medicinal Chemistry, Hoshi University
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Inoue Mai
Institute Of Medicinal Chemistry Hoshi University
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Higashiyama Kimio
Institute Of Medicinal Chemistry Hoshi University
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Higashiyama K
Faculty Of Pharmaceutical Sciences Okayama University
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