Automatic System for the Assay of Guanidino Compounds to Assess Uremic Status
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概要
- 論文の詳細を見る
An automated system for HPLC-fluorometry of serum guanidino compounds was constructed. This system accomplished simultaneous removal of protein and uremic fluorescences, abundant in the sera of uremic patients, which interfere with the fluorometric assay. This system was applied to the detailed elucidation of the behavior of guanidinosuccinic acid and methylguanidine during and after hemodialysis therapy (HD). The uremic patients who are capable of excreting urine even under hemodialysis therapy showed low serum guanidinosuccinic acid and methylguanidine levels. The prolongation of the interval between HD for one of the patients capable of excreting urine was examined. The levels of guanidinosuccinic acid and methylguanidine did not significantly increase and no hazardous effect was observed by 2 d of prolongation.
- 公益社団法人日本薬学会の論文
- 2000-09-01
著者
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Kinoshita Takayoshi
Analytical Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Kubo H
New Product Research Laboratories Ii Daiichi Pharmaceutical Company Ltd.
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KUBO Hajime
Faculty of Medicinal Chemistry; Hoshi University
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KUBO Hiroaki
School of Pharmaceutical Sciences, Kitasato University
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SUZUKI Junko
School of Agriculture, Ibaraki University
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Watanabe Mitsuo
School Of Pharmaceutical Sciences Teikyo Univ.
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Watanabe M
School Of Pharmaceutical Sciences Teikyo Univ.
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Watamabe Minae
Faculty Of Pharmaceutical Sciences Setsunan University
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Kinoshita T
School Of Pharmaceutical Sciences Kitasato Univ.
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NOHARA Yukio
Faculty of Pharmaceutical Sciences, Teikyo University
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MATSUMOTO Gou
Department of Medicine, Matsumoto Hospital
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KINOSHITA Toshio
School of Pharmaceutical Sciences, Kitasato University
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WATANABE Mitsuo
Faculty of Pharmaceutical Sciences, Teikyo University
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HANAI Toshihiko
International Institute of Technological Analysis, Health Research Foundation
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IINUMA Fumio
Faculty of Pharmaceutical Sciences, Teikyo University
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Iinuma F
Faculty Of Pharmaceutical Sciences Teikyo University
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Matsumoto Gou
Department Of Medicine Matsumoto Hospital
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Hanai Toshihiko
International Institute Of Technological Analysis Health Research Foundation
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Hanai Toshihiko
International Inst. Of Technological Analysis Health Res. Foundation
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Kinoshita Toshio
School Of Pharmaceutical Sciences Kitasato University
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Kubo Hiroaki
School Of Pharmaceutical Sciences Kitasato University
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Watanabe Mitsuo
Faculty Of Pharmaceutical Sciences University Of Teikyo
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Suzuki Junko
School Of Agriculture Ibaraki University
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Suzuki J
School Of Pharmacy Kitasato Univ.
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