Chemiluminescence-HPLC for the Assay of Guanidino Compounds
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概要
- 論文の詳細を見る
A chemiluminescence-HPLC system for the assay of serum guanidino compounds was established. In this study, we found that lucigenin added to the reaction mixture containing guanidino compounds and alkaline-ninhydrin reagent resulted in strong chemiluminescence. The lucigenin chemiluminescence was not derived from fluorescent derivatives of guanidino compounds or ninhydrin. The interaction of guanidino compounds and ninhydrin under alkaline conditions produced reactive oxygen species. We applied this phenomenon to the microanalysis of guanidino compounds.
- 公益社団法人日本薬学会の論文
- 2000-11-01
著者
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Kinoshita Takayoshi
Analytical Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Watanabe Mitsuo
School Of Pharmaceutical Sciences Teikyo Univ.
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Watanabe M
School Of Pharmaceutical Sciences Teikyo Univ.
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Watamabe Minae
Faculty Of Pharmaceutical Sciences Setsunan University
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Kinoshita T
School Of Pharmaceutical Sciences Kitasato Univ.
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NOHARA Yukio
Faculty of Pharmaceutical Sciences, Teikyo University
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KINOSHITA Toshio
School of Pharmaceutical Sciences, Kitasato University
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WATANABE Mitsuo
Faculty of Pharmaceutical Sciences, Teikyo University
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HANAI Toshihiko
International Institute of Technological Analysis, Health Research Foundation
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Hanai Toshihiko
International Institute Of Technological Analysis Health Research Foundation
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Hanai Toshihiko
International Inst. Of Technological Analysis Health Res. Foundation
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Kinoshita Toshio
School Of Pharmaceutical Sciences Kitasato University
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Watanabe Mitsuo
Faculty Of Pharmaceutical Sciences University Of Teikyo
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