Absolute Structure of Panaxytriol
スポンサーリンク
概要
- 論文の詳細を見る
Diastereomeric mixture at C-3 of(9R, 10R)-panaxytriol acetonide(3)and(9S, 10S)-panaxytriol acetonide(4)were enantioselectively acetylated to give(3R)-acetates(3a-Ac, 4a-Ac)and(3S)-alcohols(3b, 4b)by enzyme mediated-acetylation using CHIRAZYME and vinyl acetate, respectively. Hydrolysis of(3R)-acetate(3a-Ac, 4a-Ac)with CHRAZYME and phosphate buffer afforded(3R)-alcohols(3a, 4a), respectively. Deprotection of panaxytriol acetonides(3a, 3b, 4a, 4b)gave panaxatriol and its isomers, respectively. Comparison of optical rotation values of the synthetic panaxatriols with that of the natural one confirmed that the absolute configuration of panaxytriol sould be 3R, 9R, 10R.
- 公益社団法人日本薬学会の論文
- 2002-01-01
著者
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UCHIYAMA Taketo
College of Pharmacy, Nihon University
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FUJIMOTO Yasuo
College of Pharmacy, Nihon University
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Watanabe Mitsuo
School Of Pharmaceutical Sciences Teikyo Univ.
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Yoshinori Fujimoto
Department Of Chemistry And Materials Science Tokyo Institute Of Technology
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Fujimoto Yoshinori
Department Of Chemistry And Materials Science Tokyo Institute Of Technology
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Ishii Masayoshi
Showa College Of Pharmaceutical Sciences
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SATOH Mitsuru
Showa College of Pharmaceutical Sciences
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WATANABE Mitsuo
Showa College of Pharmaceutical Sciences
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ISOBE Kimiaki
Showa College of Pharmaceutical Sciences
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Satoh M
Showa Pharmaceutical University
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Isobe K
Showa College Of Pharmaceutical Sciences
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Isobe Kimiaki
Showa Pharmaceutical University
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Watanabe M
School Of Pharmaceutical Sciences Teikyo Univ.
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Watamabe Minae
Faculty Of Pharmaceutical Sciences Setsunan University
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Fujimoto Yasuo
Department Of General Studies College Of Humanities And Sciences Nihon University
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Fujimoto Yasuo
College Of Humanities And Sciences Nihon University
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Uchiyama Taketo
College Of Pharmacy Nihon University
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