Elucidation of Anti-allergic Activities of Curcumin-Related Compounds with a Special Reference to Their Anti-oxidative Activities(Medicinal Chemistry)
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概要
- 論文の詳細を見る
The anti-allergic and anti-oxidative activities of curcumin-related compounds (glycosides, reductants and bis-demethoxy analogs) were investigated to elucidate the underlying active mechanisms and structural features of curcumin in exerting these activities. The anti-allergic activities were assessed by measurement of histamine release from rat basophilic leukemia cells, RBL-2H3. Curcumin and tetrahydrocurcumin (THC) caused a marked decrease in histamine release. Glycosides of curcumin, bis-demethoxycurcumin and THC also inhibited the release of histamine, though less potently than curcumin did. The anti-oxidative activities were assessed by measurement of cell-free or cellular radical scavenging. All compounds but diglycosides or bis-demethoxycurcumin analogs distinctly exerted anti-oxidative effects. The relationship between both of these activities revealed that all compounds with potent radical scavenging activities caused a definite decrease in histamine release, but some compounds with non-potent radical scavenging activities also inhibited the histamine release. These results suggest that the hydroxy groups of curcumin play a significant role in exerting both the anti-oxidative and antiallergic activities, and that most of the compounds develop the anti-allergic activities through mechanisms related to anti-oxidative activities, but some through mechanisms unrelated to anti-oxidation activity.
- 公益社団法人日本薬学会の論文
- 2005-08-01
著者
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毛利 邦彦
Showa College Of Pharmaceutical Sciences
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NAKAMURA Tomonori
Graduate School of Pharmaceutical Sciences, Chiba University
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YANO Shingo
Graduate School of Pharmaceutical Sciences, Chiba University
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Suzuki Makoto
Graduate School of Engineering, Tohoku Univeristy
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FUJIWARA Akihiro
Graduate School of Information Science, Nara Institute of Science and Technology
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ISOBE Kimiaki
Showa College of Pharmaceutical Sciences
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MOHRI Kunihiko
Showa Pharmaceutical University
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WATANABE Yuhya
Showa Pharmaceutical University
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Mohri K
Showa College Of Pharmaceutical Sciences
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Yano S
Laboratory Of Molecular Pharmacology And Pharmacotherapeutics Graduate School Of Pharmaceutical Scie
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Isobe K
Showa College Of Pharmaceutical Sciences
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Isobe Kimiaki
Showa Pharmaceutical University
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Ono Kageyoshi
Laboratory Of Molecular Pharmacology And Pharmacotherapeutics Graduate School Of Pharmaceutical Scie
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Nakamura Tomonori
千葉大学 薬学研究院高齢者薬物学
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IYOKI Sachi
Graduate School of Pharmaceutical Sciences, Chiba University
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ONO Kageyoshi
Graduate School of Pharmaceutical Sciences, Chiba University
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Yano Shingo
Laboratory Of Molecular Pharmacology And Pharmacotherapeutics Graduate School Of Pharmaceutical Scie
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Iyoki Sachi
Graduate School Of Pharmaceutical Sciences Chiba University
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Nakamura Tomonori
Graduate School Of Pharmaceutical Sciences Chiba University
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Nakamura Tomonori
Dept Of Mol. Pharmacol. & Pharmacother Grad. Sch. Pharm. Sci. Chiba Univ.
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Yano Shingo
Department Of Molecular Pharmacology And Pharmacotherapeutics Graduate School Of Pharmaceutical Scie
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Fujiwara Akihiro
Graduate School Of Pharmaceutical Sciences Chiba University
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Suzuki Makoto
Graduate School Of Engineering Tohoku University:crest Jst
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Suzuki Makoto
Graduate School Of Engineering Tohoku Univ
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Yano Shingo
Graduate School Of Pharmaceutical Sciences Chiba University
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