Abatement of Morphine-Induced Slowing in Gastrointestinal Transit by Dai-kenchu-to, a Traditional Japanese Herbal Medicine
スポンサーリンク
概要
- 論文の詳細を見る
As a way of alleviating severe constipation in cancer patients taking morphine to relieve pain, effects of Dai-kenchu-to (DKT), a traditional Japanese herbal medicine (Kampo medicine), on gastrointestinal transit in mice or on the isolated guinea pig ileum were studied in special reference to morphine. Without altering the anti-nociceptive effect of morphine, DKT was significantly effective against morphine-induced disorder of gastrointestinal transit in mice as assessed by the charcoal meal test for the intestine and measurement of transit time for the colon tract. The results of in vitro studies with guinea pig ileum suggest that abatement of morphine-induced disorder of transit by DKT is caused by both moderate contraction of morphine-treated longitudinal muscle and relaxation of morphine-induced tonic contraction of circular muscle.
- 社団法人 日本薬理学会の論文
- 2002-02-01
著者
-
Ueno Koichi
Laboratory Of Biochemical Pharmacology And Biotoxicology Faculty Of Pharmaceutical Sciences Chiba Un
-
Ueno K
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
-
Ueno K
Laboratory Of Biochemical Pharmacology And Biotoxicology Faculty Of Pharmaceutical Sciences Chiba Un
-
Noda K
Laboratories Of Molecular Pharmacology And Pharmacotherapeutics Graduate School Of Pharmaceutical Sc
-
Ueno Koichi
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog
-
Ueno Koichi
Departments Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Ch
-
Yano S
Laboratory Of Molecular Pharmacology And Pharmacotherapeutics Graduate School Of Pharmaceutical Scie
-
Yano Shingo
Laboratory Of Molecular Pharmacology & Pharmacotherapeutics Graduate School Of Pharmaceutical Sc
-
Nakamura Tomonori
千葉大学 薬学研究院高齢者薬物学
-
SAKAI Akiko
Laboratory of Ecology, Faculty of Science, Chiba University
-
NAKAMURA Tomonori
Laboratory of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sci
-
ISOGAMI Issei
Laboratory of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sci
-
NODA Kazuhiro
Laboratories of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical S
-
Yano Shingo
Laboratory Of Molecular Pharmacology And Pharmacotherapeutics Graduate School Of Pharmaceutical Scie
-
Ueno K
Kinki Univ. Nara Jpn
-
Ueno Koichi
Dep. Of Geriatric Pharmacology Graduate School Of Pharmaceutical Sciences Chiba Univ.
-
Sakai Akiko
Laboratories Of Molecular Pharmacology And Pharmacotherapeutics Graduate School Of Pharmaceutical Sc
-
Nakamura Tomonori
Dept Of Mol. Pharmacol. & Pharmacother Grad. Sch. Pharm. Sci. Chiba Univ.
-
Isogami Issei
Laboratory Of Molecular Pharmacology And Pharmacotherapeutics Graduate School Of Pharmaceutical Scie
-
Yano Shingo
Department Of Molecular Pharmacology And Pharmacotherapeutics Graduate School Of Pharmaceutical Scie
-
Ueno Koichi
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
-
YANO Shingo
Laboratory of Chemical Pharmacology, Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University
-
UENO Koichi
Laboratory of Biochemical Pharmacology and Biotoxicology
関連論文
- Expression of histamine H4 receptor in human epidermal tissues and attenuation of experimental pruritus using H4 receptor antagonist
- The structure-activity relationship between oxycoumarin derivatives showing inhibitory effects on iNOS in mouse macrophage RAW264.7 cells
- Enhanced Effect of Connexin 43 on Cisplatin-Induced Cytotoxicity in Mesothelioma Cells
- A New Lignan from Balanophora abbreviata and Inhibition of Lipopolysaccharide (LPS)-induced Inducible Nitric Oxide Synthase (iNOS) Expression
- Establishment and Pathophysiological Characterization of Type 2 Diabetic Mouse Model Produced by Streptozotocin and Nicotinamide(Highlighted paper selected by Editor-in-chief,Pharmacology)
- Comparative study of histamine H4 receptor expression in human dermal fibroblasts
- Expression of Histamine H4 Receptor in Synovial Cells from Rheumatoid Arthritic Patients(Biopharmacy)
- Histamine H4 Receptor Expression in Human Synovial Cells Obtained from Patients Suffering from Rheumatoid Arthritis(Biopharmacy)
- Connexin 32 as an Anti-invasive and Anti-metastatic Gene in Renal Cell Carcinoma
- Cytotoxic Effect of the Her-2/Her-1 Inhibitor PKI-166 on Renal Cancer Cells Expressing the Connexin 32 Gene
- ATTENUATION OF ASPIRIN ANALGESIA BY CALCIUM LOADING IN HEALTHY SUBJECTS
- CHARACTERIZATION AND PURIFICATION OF VARIOUS CARBOXYLESTERASE ISOZYMES FROM RAT LIVER MICROSOME
- NAD-MEDIATED POTENTIATION OF ANTI-CARBOXYLESTERASE ACTION OF EPN (5); PARTICIPATION OF MICROSOMAL DEHYDROGENASE (S)
- IN VIVO INHIBITION OF LIPID PEROXIDE FORMATION BY CLOFIBRATE IN THE RAT
- SPECIES DIFFERENCE IN GLUTATHIONE LEVEL AND GLUTATHIONE RELATED ENZYME ACTIVITIES IN RATS, MICE, GUINEA PIGS AND HAMSTERS
- THE EFFECTS OF ASPIRIN AND ITS METABOLITE, SALICYLIC ACID, ON CULTURED RAT EMBRYO
- INDUCTION OF HEPATIC GLUTATHIONE S-TRANSFERASE ACTIVITIES BY REPEATED ADMINISTRATION OF AMINOPYRINE IN RATS
- PERTURBATION OF HEPATIC GLUTATHIONE LEVEL AND GLUTATHIONE RELATED ENZYME ACTIVITIES BY REPEATED ADMINISTRATION OF AMINOPYRINE IN RATS
- CHANGES OF GAMMA-GLUTAMYLTRANSPEPTIDASE ACTIVITY IN THE RAT DURING DEVELOPMENT AND COMPARISON OF THE FETAL LIVER, PLACENTAL AND ADULT LIVER ENZYMES
- ACETYLSALICYLIC ACID INDUCED FETALTOXICITY AND DRUG METABOLISM
- "P-32 In vitro liver injury model induced by P. acnes-LPS in multicellular sphroids composed of rat liver cells formed by rotary culture system.
- "A-2 THE MECHANISM OF HEPATIC COPPER ACCUMULATION IN THE SPHEROID COMPOSED OF LEC RAT LIVER CELLS IN VITRO
- CYTOKINE-DEPENDENT IN VITRO RAT LIVER INJURY INDUCED BY P.ACNES AND LPS.
- HEPATIC COPPER ACCUMULATION OF SPHEROID COMPOSED OF LEC RAT LIVER CELLS IN VITRO
- GENERAL PHARMACOLOGICAL STUDIES OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE IN EXPERIMENTAL ANIMALS
- Induction of Cytochrome P450 1A1 in Mice by Repeated Oral Administration of Propranolol
- Inactivation of Rat Cytochrome P450 2D Enzyme by a Further Metabolite of 4-Hydroxypropranolol, the Major and Active Metabolite of Propranolol
- Fluorescence Detection of DNA Using a Novel Peroxidase Substrate, 4-(4-Hydroxyphenylcarbamoyl)butanoic Acid
- A Novel Method for Determining Peroxidase Activities Using ρ-Acetamidophenol Analogs
- Formaldehyde-Induced Shrinkage of Rat Thymocytes
- EFFECT OF PRENATAL EXPOSURE OF PARATHION ON HUMORAL IMMUNE FUNCTION IN MICE
- BASAL INVESTIGATION ON THE INTRODUCTION OF DRUG METABOLIZING SYSTEM INTO RAT WHOLE EMBBYO CULTURE SYSTEM
- ON THE DIFFERENT FUNCTION OF CYTOCHROME P-450 ISOZYMES IN LIPID PEROXIDATION
- EFFECTS ON OFFSPRING INDUCED BY ORAL ADMINISTRATION OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE TO THE FEMALE RATS IN PERI-AND POST-NATAL PERIODS
- TERATOLOGICAL STUDY OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE IN RABBITS
- TERATOLOGICAL STUDIES OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE IN RATS
- STUDIES OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE ON FERTILITY IN RATS
- Effect of Pentobarbital on Gastric Acid Secretion Elicited by Secretagogues or Electrical Vagal Stimulation in Rats under Urethane Anesthesia
- Contractile effect of TRPA1 receptor agonists in isolated mouse colon
- A Combined Assay of Cell Vability and in Vitro Cytotoxicity with a Highly Water-Soluble Tetrazolium Salt, Neutral Red and Crystal Violet
- Benzothiazole-Containing Tetrazolium Salts That Produce Water-Soluble Formazan Dyes Absorbing at a Long Wavelength upon NADH Reduction
- 2-(5-Hydrazinocarbonyl-2-oxazolyl)-5,6-dimethoxybenzothiazole as a precolumn fluorescence derivatization reagent for carboxylic acids in high-performance liquid chromatography and its application to the assay of fatty acids in human serum
- 2-(5-Hydrazinocarbonyl-2-furyl)-5, 6-dimethoxybenzothiazole as a Precolumn Fluorescence Derivatization Reagent for Carboxylic Acids in High-Performance Liquid Chromatography and Its Application to the Assay of Fatty Acids in Human Serum
- Adaptive Significance of Sprouting of Euptelea polyandra, a Deciduous Tree Growing on Steep Slopes with Shallow Soil
- Size-Regulation and Biochemical Activities of The Multicellular Spheroid Composed of Rat Liver Cells
- 329 Productton of Experimental Acute Liver Injury Model Using Multicellular Spheroids Composed of Rat Parenchymal and Non-parenchymal Liver Cells
- Effect of Nonspecific Binding to Microsomes and Metabolic Elimination of Buprenorphine on the Inhibition of Cytochrome P4502D6(Biochemistry/Molecular Biology)
- Inhibitory effect of the extracts from Thai medicinal plants on iNOS expression in mouse macrophage RAW 264.7
- Inhibitory effect of oxycoumarins isolated from the Thai medicinal plant Clausena guillauminii on the inflammation mediators, iNOS, TNF-α, and COX-2 expression in mouse macrophage RAW 264.7
- Memory and learning-enhancing effect of Daikenchuto, a traditional Japanese herbal medicine, in mice
- Inhibition of the Antibody Production by Acetaminophen Independent of Liver Injury in Mice
- Abatement of Morphine-Induced Slowing in Gastrointestinal Transit by Dai-kenchu-to, a Traditional Japanese Herbal Medicine
- O11-09 Reproductive Immunotoxicity of di-(2-ethyihexyl phthalate(DEHP)in rats
- P-10. Fish micronucleus test using kidney, gill and erythrocytes(Abstracts of the oral and poster presentations)(The 53rd Annual Meeting of the Society of Chromosome Research)
- P-09. Micronucleus test using erythrocytes of Carassius species and Zacco platypus for monitoring genotoxic pollutants in river water(Abstracts of the oral and poster presentations)(The 53rd Annual Meeting of the Society of Chromosome Research)
- Chromosome Aberrations and Survival in Normal and Dechorionated Embryos of Misgurnus anguillicaudatus (Cobitidae, Pisces) Exposed to Mitomycin C
- PRODUCTION OF EXPERIMENTAL ACUTE LIVER INJURY MODEL USING THE MULTICELLULAR SPHEROIDS COMPOSED OF RAT LIVER CELLS.
- FORMATION AND LONG-TERM CULTURE OF SPHEROID COMPOSED OF LONG-EVANS CINNAMON(LEC)RAT LIVER CELLS
- Pharmacological Characterization of 5-Hydroxytryptamine-Receptor Subtypes in Circular Muscle from the Rat Stomach(Pharmacology)
- Elucidation of Anti-allergic Activities of Curcumin-Related Compounds with a Special Reference to Their Anti-oxidative Activities(Medicinal Chemistry)
- INFLUENCE OF MATERNAL DRUG METABOLISM ON THE FETAL TOXICITY INDUCED BY ACETYLSALICYLIC ACID
- NAD-Coupled Enzymatic Oxidation of O-Ethyl O-p-Nitrophenyl Phenylphosphonothioate (EPN) to Its Oxygen Analog with Liver Microsomes of Rats
- HYPOCALCEMIC EFFECT OF ACETYLSALICYLIC ACID IN RATS
- Stimulatory Effects of Nitric Oxide Donors on Histamine Release in Isolated Rat Gastric Mucosal Cells
- Vegetation pattern and microtopography on a landslide scar of Mt Kiyosumi, central Japan
- Topographical pattern of the forest vegetation on a river basin in a warm - temperate hilly region, central Japan
- ASPIRIN INHIBITION OF HYPERCALCEMIC EFFECT OF 1α-HYDROXYVITAMIN D3 IN RATS
- Comparison of Effects of Famotidine on Vagally and Field - Electrically Stimulated Acid Secretion in the Isolated Mouse Whole Stomach
- Pharmacological Features of Non-adrenergic Non-cholinergic (NANC) Relaxation Induced by Electrical Vagal Stimulation in Isolated Mouse Stomach
- A novel animal model of pruritus induced by successive application of glucocorticoid to mouse skin
- Antiallergic Activity of Curcuma longa (II) : Features of inhibitory actions on histamine release from mast cells
- Antiallergic Activity of Curcuma longa (I) : Effectiveness of Extracts Containing Curcuminoids
- Acetaminophen enhances pruritus in a mouse model of contact dermatitis induced by suboptimal concentration of hapten
- The Histamine H_2-Receptor Antagonist, Cimetidine, Inhibits the Articular Osteopenia in Rats With Adjuvant-Induced Arthritis by Suppressing the Osteoclast Differentiation Induced by Histamine
- Antiallergic Activity of Curcuma longa (II) : Features of inhibitory actions on histamine release from mast cells
- New 2-Aryl-1,4-naphthoquinone-1-oxime Methyl Ether Compound Induces Microtubule Depolymerization and Subsequent Apoptosis
- Effects of heptaminol AMP amidate on suppressor and helper function of murine T cells.
- Effects of heptaminol AMP amidate(HAA) on cyclic AMP level and mitogen-induced proliferation of murine spleen cells.
- Enhancement of the binding of O-ethyl O-p-nitrophenyl phenylphosphonate (EPNoxon) to microsomal carboxylesterase by NAD in vitro.
- Effect of heptaminol AMP amidate, a new nucleotide derivative, on in vitro humoral immunity.
- Inhibitory effect of intravenous GABA antagonists on gastric acid secretion stimulated by secretagogues in rats.
- Centrally mediated inhibitory effect of 5-(2-(diethylamino)ethyl)amino-5,11-dihydro(1)benzoxepino(3,4-b)pyridine trihydrochloride (KW-5805) on gastric acid secretion in rats.
- Vasoconstrictor effect of endothelin in isolated perfused stomach of the rat in comparison with noradrenaline and serotonin.
- Comparative Effects of Cimetidine and Famotidine on the Vagally Stimulated Acid Secretion in the Isolated Mouse Whole Stomach.
- Effects of co-administration of monomethylaminoantipyrine and cobaltous chloride on hepatic glutathione level and glutathione-related enzyme activities in rats.
- Potentiation of EPN-induced inhibition of liver microsomal carboxylesterase by addition of liver cytosol from 6-aminonicotinamide-treated, starved rats.