Stimulatory Effects of Nitric Oxide Donors on Histamine Release in Isolated Rat Gastric Mucosal Cells
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概要
- 論文の詳細を見る
We previously reported stimulatory effects of endogenous and exogenous nitric oxide (NO) on gastric acid secretion. In the present study, we investigated effects of NO donors on release of histamine, which is related to acid secretion, in isolated rat gastric mucosal cells. NO donors such as (±)-(E)-4-methyl-2-[(E)-hydroxyimino]-5- nitro-6-methoxy-3-hexanamide (NOR 1) and sodium nitroprusside significantly augmented the histamine release. It was inhibited by 2-(4-carboxyphenyl)-4,4,5,5,-tetramethylimidazoline-1-oxyl-3-amide (carboxy-PTIO), a NO scavenger, and 6-(phenylamino)-5,8-quinolinedione (LY83583), a soluble guanylate cyclase inhibitor. Dibutyryl cyclic GMP also stimulated histamine release. These results suggest that NO donors act on cyclic GMP pathway in isolated gastric mucosal cells, resulting in facilitation of histamine release. NO may stimulate gastric acid secretion through histamine release from the histamine-containing cells, possibly enterochromaflfin-like cells.
- 公益社団法人日本薬学会の論文
- 2003-07-01
著者
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Yano S
Laboratory Of Molecular Pharmacology And Pharmacotherapeutics Graduate School Of Pharmaceutical Scie
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Yano Shingo
Laboratory Of Molecular Pharmacology & Pharmacotherapeutics Graduate School Of Pharmaceutical Sc
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Horie Syunji
Laboratory Of Pharmacology Faculty Of Pharmaceutical Sciences Josai International University
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Horie S
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University
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Horie Syunji
Laboratory Of Chemical Pharmacology Chiba University
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WATANABE Kazuo
Laboratory of Chemical Pharmacology, Department of Drug Evaluation and Toxicological Sciences, Facul
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Hasebe K
Laboratory Of Chemical Pharmacology Chiba University
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Horie S
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Sciences Teikyo University
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Yano Shingo
Laboratory Of Molecular Pharmacology And Pharmacotherapeutics Graduate School Of Pharmaceutical Scie
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Watanabe Kazuo
Hokkaido Pharmaceutical University School Of Pharmacy
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HASEBE Ko
Laboratory of Chemical Pharmacology, Chiba University
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Yano Shingo
Department Of Molecular Pharmacology And Pharmacotherapeutics Graduate School Of Pharmaceutical Scie
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Watanabe Kazuo
Laboratory Of Applied Botany Faculty Of Agriculture Kyoto University
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Watanabe Kazuo
Laboratory Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
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YANO Shingo
Laboratory of Chemical Pharmacology, Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University
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