Gastric Acid Secretion by Central Injection of Dynorphin A-(1-17), an Endogenous Ligand of κ-Opioid Receptor, in Urethane-Anesthetized Rats
スポンサーリンク
概要
- 論文の詳細を見る
Gastric acid secretion has been proposed to be regulated by opioid receptors in the central nervous system (CNS). Previously, we reported that central injection of synthetic agonists of κ-opioid receptors stimulated gastric acid secretion in rats, and the secretion by the agonists was inhibited by norbinaltorphimine (an antagonist of κ-opioid receptor). In the present study, we investigated the effect of dynorphin A-(1 – 17), an endogenous ligand of κ-opioid receptor on the gastric acid secretion in the perfused stomach of urethane-anesthetized rats. Injection of dynorphin A-(1 – 17) (0.1 – 1 μg per rat) into the lateral cerebroventricle (LV) stimulated the secretion in a dose-dependent manner. The effect of dynorphin A-(1 – 17) was almost completely inhibited by the LV injection of norbinaltorphimine (10 μg) and in vagotomized rats. Although some studies of dynorphin A-(1 – 17) after central injection showed non-opioid effects such as the involvement of N-methyl-<sc>D</sc>-aspartate (NMDA) receptor, the effect of dynorphin A-(1 – 17) was not inhibited by a selective antagonist of the NMDA receptor ((±)-3-(2-carboxypiperazin-4-yl)-1-propylphosphonic acid, 10 μg). The LV injection of naloxone benzoylhydrazone (a κ3-opioid receptor agonist, 100 μg) also stimulated the secretion in norbinaltorphimine-sensitive manner. These findings showed that both an endogenous ligand dynorphin A-(1 – 17) and a synthetic κ3-opioid receptor agonist stimulated gastric acid secretion via κ-opioid receptors in the CNS of rats in vivo.
- 社団法人 日本薬理学会の論文
- 2001-09-01
著者
-
Sekine T
Graduate School Of Pharmaceutical Sciences Chiba University
-
Horie Syunji
Laboratory Of Pharmacology Faculty Of Pharmaceutical Sciences Josai International University
-
Horie S
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University
-
Horie Syunji
Laboratory Of Chemical Pharmacology Chiba University
-
Murayama T
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University
-
Murayama Toshihiko
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University
-
Murayama Toshihiko
Laboratory Of Chemical Pharamacology Graduate School Of Pharmaceutical Sciences Chiba University
-
WATANABE Kazuo
Laboratory of Chemical Pharmacology, Department of Drug Evaluation and Toxicological Sciences, Facul
-
Horie S
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Sciences Teikyo University
-
Murayama Toshihiko
Lab. Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba Univ. Jpn
-
Tsuchiya Shizuko
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University
-
Tsuchiya Shizuko
Department Of Molecular Pharmacology And Pharmacotherapeutics Graduate School Of Pharmaceutical Scie
-
Watanabe Kazuo
Hokkaido Pharmaceutical University School Of Pharmacy
-
ISHIHARA Satomi
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University
-
Ishihara Satomi
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University
-
Watanabe Kazuo
Laboratory Of Chemical Pharmacology Department Of Drug Evaluation And Toxicological Sciences Faculty
-
Tsuchiya Shizuko
Department Of Molecular Pharmacology And Pharmacotherapeutics Graduate School Of Pharmaceutical Scie
-
Tsuchiya Shizuko
Dept Of Mol. Pharmacol. & Pharmacother Grad. Sch. Pharm. Sci. Chiba Univ.
-
Watanabe Kazuo
Laboratory Of Applied Botany Faculty Of Agriculture Kyoto University
-
Watanabe Kazuo
Laboratory Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
-
Tsuchiya Shizuko
Laboratory Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
関連論文
- The structure-activity relationship between oxycoumarin derivatives showing inhibitory effects on iNOS in mouse macrophage RAW264.7 cells
- Effects of Synthetic Sphingosine-1-Phosphate Analogs on Cytosolic Phospholipase A2α–Independent Release of Arachidonic Acid and Cell Toxicity in L929 Fibrosarcoma Cells: the Structure–Activity Relationship
- Activation of Cytosolic Phospholipase A_2α by Epidermal Growth Factor (EGF) and Phorbol Ester in HeLa Cells : Different Effects of Inhibitors for EGF Receptor, Protein Kinase C, Src, and C-Raf
- Effects of Synthetic Sphingosine-1-Phosphate Analogs on Cytosolic Phospholipase A_2α-Independent Release of Arachidonic Acid and Cell Toxicity in L929 Fibrosarcoma Cells : the Structure-Activity Relationship
- Activation of Cytosolic Phospholipase A2α by Epidermal Growth Factor (EGF) and Phorbol Ester in HeLa Cells: Different Effects of Inhibitors for EGF Receptor, Protein Kinase C, Src, and C-Raf
- 味認識装置による漢方処方の味の評価に関する研究(第2報)葛根湯に関する検討
- Effect of CAWS, a Mannoprotein-β-glucan Complex of Candida albicans, on Leukocyte, Endothelial Cell, and Platelet Functions in Vitro
- A New Lignan from Balanophora abbreviata and Inhibition of Lipopolysaccharide (LPS)-induced Inducible Nitric Oxide Synthase (iNOS) Expression
- Chemical Constituents of Bauhinia sirindhorniae
- A New ent-Clerodane Diterpene from the Aerial Parts of Baccharis gaudichaudiana
- Ardisiphenols and Other Antioxidant Principles from the Fruits of Ardisia colorata
- A New Pentacyclic Cucurbitane Glucoside and a New Triterpene from the Fruits of Gymnopetalum integrifolium
- Ardisiphenols A-C, Novel Antioxidants from the Fruits of Ardisia colorata
- Depressive Behavior and Alterations in Receptors for Dopamine and 5-Hydroxytryptamine in the Brain of the Senescence Accelerated Mouse (SAM)-P10
- PHARMACOLOGICAL EVALUATION OF ALPHA-1 AND ALPHA-2 ADRENOCEPTOR BLOCKING ACTIVITIES AND Ca^ ENTRY BLOCKING ACTIVITY OF ALKALOIDS CONTAINED IN UNCARIA HOOKS AND THEIR RELATED DERIVATIVES
- Synthesis and Pharmacological Activity of O-(5-Isoxazolyl)-L-serine
- Effects of Progesterone and Norethisterone on Cephalexin Transport and Peptide Transporter PEPT1 Expression in Human Intestinal Cell Line Caco-2(Pharmacology)
- Effects of Progesterone and Norethisterone on Cephalexin Uptake in the Human Intestinal Cell Line Caco-2 (Biopharmacy)
- Studies on Intestinal Absorption of Sulpiride (3) : Intestinal Absorption of Sulpiride in Rats(Biopharmacy)
- Studies on Intestinal Absorption of Sulpiride (2) : Transepithelial Transport of Sulpiride Across the Human Intestinal Cell Line Caco-2(Biopharmacy)
- Studies on Intestinal Absorption of Sulpiride (1) : Carrier-Mediated Uptake of Sulpiride in the Human Intestinal Cell Line Caco-2
- Activation of Ceramidase and Ceramide Kinase by Vanadate via a Tyrosine Kinase–Mediated Pathway
- Possible Role of Interleukin-6 in PC12 Cell Death Induced by MPP^+ and Tetrahydroisoquinoline
- Inhibitory Effect of Cilnidipine on Vascular Sympathetic Neurotransmission and Subsequent Vasoconstriction in Spontaneously Hypertensive Rats
- Inhibitory Effect of Cilnidipine on Pressor Response to Acute Cold Stress in Spontaneously Hypertensive Rats
- Effect of Pentobarbital on Gastric Acid Secretion Elicited by Secretagogues or Electrical Vagal Stimulation in Rats under Urethane Anesthesia
- Contractile effect of TRPA1 receptor agonists in isolated mouse colon
- Gastric Acid Secretion Is Augmented by the Replacement of Extracellular Na^+ With K^+ or Other Ions
- Change in Formation of Gastric Lesions by Aspirin during Aging in Rats
- Involvement of Metabolites in the Inhibitory Effects of 2-(4-Ethyl-1-piperazinyl)-4-phenylquinoline Dimaleate (AD-2646), a New Quinoline Derivative, on Gastric Acid Secretion. A Comparison with Tricyclic Antidepressants
- Expression of Cytosolic Phospholipase A_2α in Murine C12 Cells, a Variant of L929 Cells, Induces Arachidonic Acid Release in Response to Phorbol Myristate Acetate and Ca^ Ionophores, but Not to Tumor Necrosis Factor-α
- Extracellular Signal Regulated Protein Kinase and c-Jun N-Terminal Kinase are Involved in m1 Muscarinic Receptor-Enhanced Interleukin-2 Production Pathway in Jurkat Cells
- Nicotine-Induced Neurogenic Relaxation in the Mouse Colon : Changes With Dextran Sodium Sulfate-Induced Colitis
- Indomethacin Decreases Arachidonic Acid Uptake in HCA-7 Human Colon Cancer Cells
- Enhancement of Phenylephrine-Induced Contraction in the Isolated Rat Aorta With Endothelium by H_2O-Extract From an Oriental Medicinal Plant Leonuri herba
- Flower-Inducing Activity of Benzoic Acid Derivatives for Lemna minor
- Increases in plasma concentration of progesterone by protease-sensitive urinary pheromones in female rats
- Lafutidine-Induced Increase in Intracellular Ca^ Concentrations in PC12 and Endothelial Cells
- EFFECTS ON GASTRIC ACID SECRETION OF A STEROIDAL ALKALOID, EPIPACHYSAMINE-A, EXTRACTED FROM PACHYSANDRA TERMINALIS SIEB.ET ZUCC
- Effect of High-intensity Light Given Prior to Low-temperature Treatment on the Long-day Flowering of Pharbitis nil
- Vosorelaxing Effect of Mesaconitine, an Alkaloid From Aconitum japonicum, on Rat Small Gastric Artery : Possible Involvement of Endothelium-Derived Hyperpolarizing Factor
- Validation of ^C-Acetic Acid Breath Test by Measuring Effects of Loperamide, Morphine, Mosapride, and Itopride on Gastric Emptying in Mice(Pharmacology)
- Quercetin-Induced PC12 Cell Death Accompanied by Caspase-Mediated DNA Fragmentation(Pharmacology)
- A Bacterial Artificial Chromosome (BAG) Library for Potato and Identification of Clones Related to the Potato Y Potyvirus Resistance Gene Ry_
- Stimulatory Effects of Nitric Oxide Donors on Histamine Release in Isolated Rat Gastric Mucosal Cells
- Stimulatory Effects of Centrally Injected Nitric Oxide Donors on Gastric Acid Secretion in Anesthetized Rats
- Gastric Acid Secretion by Central Injection of Dynorphin A-(1-17), an Endogenous Ligand of κ-Opioid Receptor, in Urethane-Anesthetized Rats
- Relationship between Structure and Flower-inducing Activity of Benzoic Acid Derivatives in Lemna paucicostata 151
- Lafutidine-Induced Increase in Intracellular Ca2+ Concentrations in PC12 and Endothelial Cells
- Modifications of Capsaicin-Sensitive Neurons in Isolated Guinea Pig Ileum by [6]-Gingerol and Lafutidine
- Expression of the Ubiquitin Ligase HRD1 in Neural Stem/Progenitor Cells of the Adult Mouse Brain
- Flower-inducing Effect of Benzoic and Salicylic Acids in Various Strains of Lemna paucicostata and L. minor
- Comparison of Effects of Famotidine on Vagally and Field - Electrically Stimulated Acid Secretion in the Isolated Mouse Whole Stomach
- Pharmacological Features of Non-adrenergic Non-cholinergic (NANC) Relaxation Induced by Electrical Vagal Stimulation in Isolated Mouse Stomach
- Regulatory Mechanism and Physiological Role of Cytosolic Phospholipase A_2(Diversity of Phospholipase A_2 Enzymes)
- Antiallergic Activity of Curcuma longa (II) : Features of inhibitory actions on histamine release from mast cells
- Antiallergic Activity of Curcuma longa (I) : Effectiveness of Extracts Containing Curcuminoids
- Effects of some metabolic inhibitors on flowering of Lemna gibba G_3, a long-day duckweed
- Inhibitory effect of Iboga-type indole alkaloids on capsaicin-induced contraction in isolated mouse rectum
- EFFECTS OF d-COCLAURINE AND d-RETICULINE, BENZYLTETRA-HYDROISOQUINOLINE ALKALOIDS, ON LEVELS OF 3,4-DIHYDROXY-PHENYLACETIC ACID AND HOMOVANILLIC ACID IN THE MOUSE STRIATUM
- Flower-inducing effects of benzoic acid and some related compounds in Lemna paucicostata 151
- Chemical Constituents of Bauhinia sirindhorniae
- Nicotine-Induced Neurogenic Relaxation in the Mouse Colon: Changes With Dextran Sodium Sulfate–Induced Colitis
- Activation of Ceramidase and Ceramide Kinase by Vanadate via a Tyrosine Kinase-Mediated Pathway
- Inhibitory effects of clinical reagents having anti-oxidative activity on transforming growth factor-β1-induced expression of α-smooth muscle actin in human fetal lung fibroblasts
- Expression of the Ubiquitin Ligase HRD1 in Neural Stem/Progenitor Cells of the Adult Mouse Brain
- Effects of Hsp90 inhibitors, geldanamycin and its analog, on ceramide metabolism and cytotoxicity in PC12 cells
- CHEMICAL AND PHARMACOLOGICAL STUDIES ON THE CONSTITUENTS OF ZEDOARY CULTIVATED IN YAKUSHIMA JAPAN
- Inhibitory effect of intravenous GABA antagonists on gastric acid secretion stimulated by secretagogues in rats.
- Centrally mediated inhibitory effect of 5-(2-(diethylamino)ethyl)amino-5,11-dihydro(1)benzoxepino(3,4-b)pyridine trihydrochloride (KW-5805) on gastric acid secretion in rats.
- Vasoconstrictor effect of endothelin in isolated perfused stomach of the rat in comparison with noradrenaline and serotonin.
- Comparative Effects of Cimetidine and Famotidine on the Vagally Stimulated Acid Secretion in the Isolated Mouse Whole Stomach.
- Expression of Cytosolic Phospholipase A2.ALPHA. in Murine C12 Cells, a Variant of L929 Cells, Induces Arachidonic Acid Release in Response to Phorbol Myristate Acetate and Ca2+ Ionophores, but Not to Tumor Necrosis Factor-.ALPHA.