Increases in plasma concentration of progesterone by protease-sensitive urinary pheromones in female rats
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概要
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Plasma progesterone concentrations in female Wistar rats after exposure to urine preparations with and without protease-treatment were measured to explore the effects of protease-sensitive pheromones on the endocrine state. Exposure to crude urine excreted from male rats induced an increase in the plasma progesterone concentration in female rats. The progesterone concentration of oestrous females increased with an increase in the protein concentration in urine samples. Exposure of females in the oestrous state to urine preparations treated with protease did not induce increases in plasma progesterone. These results suggest that the presence of a protease-sensitive component in male urine exerts an influence on the endocrine state of oestrous females. Key Words: progesterone, rat, urine, vomeronasal system, pheromone
- 公益社団法人日本薬学会の論文
- 2005-09-01
著者
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MURAYAMA Toshihiko
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University
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KASHIWAYANAGI Makoto
Department of Sensory Physiology, Asahikawa Medical College
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Murayama Toshihiko
Laboratory Of Chemical Pharamacology Graduate School Of Pharmaceutical Sciences Chiba University
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TOMIOKA Mayumi
Graduate School of Pharmaceutical Sciences, Hokkaido University
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Kashiwayanagi Makoto
Department Of Sensory Physiology Asahikawa Medical College
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Tomioka Mayumi
Graduate School Of Pharmaceutical Sciences Hokkaido University
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Kashiwayanagi Makoto
Department of Physiology, Division of Sensory Physiology, Asahikawa Medical University
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