Expression of the Ubiquitin Ligase HRD1 in Neural Stem/Progenitor Cells of the Adult Mouse Brain
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概要
- 論文の詳細を見る
Neural stem/progenitor cells (NSCs) reside in the subventricular zone (SVZ) and subgranular zone of the hippocampal dentate gyrus in adult mammals. The ubiquitin ligase HRD1 is associated with degradation of amyloid precursor protein and believed to be specifically expressed in neurons and not in astrocytes. We investigated expression of HRD1 using immunohistochemistry and found colocalization of HRD1 with the NSC marker protein nestin and glial fibrillary acidic protein in the NSCs of the SVZ (the SVZ astrocytes) but not in the hippocampus. In the hippocampal dentate gyrus, HRD1 is localized in the nucleus of nestin-positive cells.
著者
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野村 靖幸
Yokohama College Of Pharmacy
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Ogita Kiyokazu
Department Of Parmacology Setsunan University
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OKUMA Yasunobu
Departmen of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Kawada Koichi
Department Of Mathematics Faculty Of Education Iwate University
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Fujino Hiromichi
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University
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Hamana Hiroshi
Department Of Applied Chemistry Faculty Of Engineering Saitama Institute Of Technology
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Murayama Toshihiko
Laboratory Of Chemical Pharamacology Graduate School Of Pharmaceutical Sciences Chiba University
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Nomura Yasuyuki
Laboratory of Pharmacotherapeutics, Yokohama College of Pharmacy, Japan
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Kaneko Masayuki
Department Of Dental Radiology Health Sciences University Of Hokkaido
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Kaneko Masayuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Science
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Mimori Seisuke
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chiba Institute of Scien
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