A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes
スポンサーリンク
概要
- 論文の詳細を見る
Human HRD1 and SEL1 are components of endoplasmic reticulum-associated degradation (ERAD), which is a retrograde transport mechanism from the ER to the cytosol for removing unfolded proteins. The expression of HRD1 and SEL1 was induced by ER stress-inducing agents and overexpression of both ER stress-responsive transcription factors, ATF6 and XBP1. Inhibition of IRE1 and ATF6 revealed that ER stress-induced HRD1 and SEL1 expressions are mediated by IRE1-XBP1- and ATF6-dependent pathways, respectively. These results suggest that the ER stress-induced ERAD gene expressions are mediated by different pathways, which are attributed to the differences in the promoter regions.
- Elsevier Scienceの論文
- 2007-11-27
著者
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野村 靖幸
Yokohama College Of Pharmacy
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Kasuga Masato
Department Of Hospital Pharmacy School Of Medicine Kobe University
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野村 靖幸
北海道大学・大学院薬学研究科医療薬学講座薬理学分野
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野村 靖幸
北海道大学薬学部薬効学講座
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野村 靖幸
北大薬
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Nomura Yasuyuki
Dep. Of Pharmacotherapeutics Yokohama Coll. Of Pharmacy Jpn
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Nomura Yasuyuki
Department Of Pharmacotherapeutics Yokohama College Of Pharmacy
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Okuma Y
Hokkaido Univ. Sapporo Jpn
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OMURA Tomohiro
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chiba Institute of Science
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Omura Tomohiro
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Science
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Okuma Yasunobu
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Sciences
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Nomura Yasuyuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hokkaido University
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Kaneko Masayuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Science
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Okuma Yasunobu
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Science
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Kaneko Masayuki
千葉科学大学
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