Correlation Between Decrease in Protein Levels of Ubiquitin Ligase HRD1 and Amyloid-β Production
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概要
- 論文の詳細を見る
Endoplasmic reticulum–associated degradation (ERAD) is a quality control mechanism in which unfolded proteins are retro-translocated to the cytosol for degradation. Our recent study showed that suppression of expression of ubiquitin ligase HRD1, which is involved in ERAD, caused amyloid precursor protein (APP) accumulation and amyloid-β (Aβ) production. Furthermore, HRD1 protein levels were significantly lower in the cerebral cortex of Alzheimer’s disease (AD) patients. To assess whether HRD1 is involved in AD pathology, we analyzed the relationship between HRD1 protein levels and Aβ production. We found that the HRD1 level was negatively correlated with the Aβ level, suggesting the possible involvement of HRD1 in Aβ generation.
- 社団法人 日本薬理学会の論文
- 2010-07-20
著者
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野村 靖幸
Yokohama College Of Pharmacy
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Kasuga Masato
Department Of Hospital Pharmacy School Of Medicine Kobe University
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OKUMA Yasunobu
Departmen of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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野村 靖幸
北海道大学・大学院薬学研究科医療薬学講座薬理学分野
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野村 靖幸
北海道大学薬学部薬効学講座
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野村 靖幸
北大薬
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Nomura Yasuyuki
Dep. Of Pharmacotherapeutics Yokohama Coll. Of Pharmacy Jpn
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Nomura Yasuyuki
Laboratory of Pharmacotherapeutics, Yokohama College of Pharmacy, Japan
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Kaneko Masayuki
Department Of Dental Radiology Health Sciences University Of Hokkaido
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Saito Ryo
Department Of Bioscience And Bioinformatics Faculty Of Computer Science And Systems Engineering Kyus
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Nomura Yasuyuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hokkaido University
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Kaneko Masayuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Science
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Saito Ryo
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Science
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Okuma Yasunobu
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Science
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Nomura Yasuyuki
Laboratory Of Pharmacotherapeutics Yokohama College Of Pharmacy
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Kaneko Masayuki
千葉科学大学
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Kaneko Masayuki
Department of Cardiology, Cardiovascular Center, Oita Oka Hospital
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