Microinjection of α-Calcitonin Gene-Related Peptide into the Hypothalamus Activates Sympathetic Outflow in Rats
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概要
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Effects of rat α-calcitonin gene-related peptide (α-CGRP)microinjected into various hypothalamic nuclei on plasma levels of catecholamines and arterial blood pressure were investigated in urethane-anesthetized rats. α-CGRP (0.05 and 0.25 nmol)microinjected into the hypothalamic paraventricular nucleus (PVN)increased the plasma level of noradrenaline (NA), but not that of adrenaline (AD), in a dose-dependent manner. A similar increase in plasma level of NA was also observed by α-CGRP (0.05 nmol)microinjected into the preoptic area (POA), anterior hypothalamus (AH), dorsomedial hypothalamus (DMH)and ventromedial hypothalamus (VMH). A significant increase in arterial blood pressure was observed by microinjection of a-CGRP (0.05 nmol)into the PVN, POA, AH and DMH, and the most prominant increase was caused by its microinjection into the PVN. Microinjection of the same dose of this peptide into the VMH, lateral hypothalamic area and posterior hypothalamus was without effect. The increase in plasma level of NA induced by α-CGRP (0.05 nmol)into the PVN was not affected by bilateral adrenalectomy. Electrical stimulation of the PVN elicited increases in plasma levels of both NA and AD. This increase in NA was abolished by chemical sympathectomy with 6-hydroxydopamine (50 mg/kg, i.v., 3 days before experiments). These results suggest that activation of the PVN by electrical stimulation elicits both sympathetic and adrenomedullary outflow. α-CGRP microinjected into the PVN selectively activates the sympathetic outflow.
著者
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OKUMA Yasunobu
Departmen of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Manabe Masanobu
Department of Anesthesia, Yamanashi Medical College
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Hirakawa Masahisa
Department Of Anesthesiology & Resuscitology Okayama University Midecal School
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Osumi Yoshitsugu
Department Of Pharmacology Faculty Of Medicine Kyoto University
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Hasegawa Takashi
Department Of Biology Division Of Natural Science International Christian University
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Yokotani Kunihiko
Department of Neuropharmacology, Program of Neural Integration, Graduate School of Medicine, Kochi University
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Hirakawa Masahisa
Departments of Anesthesiology, Kochi Medical School
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Osumi Yoshitsugu
Departments of,Pharmacology, Kochi Medical School
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Okuma Yasunobu
Departments of,Pharmacology, Kochi Medical School
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