Central site of inhibitory action of bombesin on gastric acid secretion in rats.
スポンサーリンク
概要
- 論文の詳細を見る
Sites of inhibitory action of bombesin on gastric acid secretion were examined in rats anesthetized with urethane. Intracerebroventricular administration of bombesin (3-1000 pmole) dose-dependently inhibited the increase in gastric acid secretion induced by electrical stimulation of the vagus nerve (1 mA, 0.5 msec, 3 Hz). On the other hand, intrathecal (direct lumbar puncture) administration of bombesin, even in the large dose of 1 nmole, had no effect on the vagally stimulated gastric acid secretion. Three pmoles of bombesin microinjected into the preoptic area, the anterior hypothalamus and the paraventricular nucleus inhibited the vagus stimulated gastric acid secretion. Microinjection of this peptide into the ventromedial nucleus, the dorsomedial nucleus and the lateral hypothalamic area were without effect. A large electrolytic lesion of the anterior hypothalamus, including the preoptic-anterior hypothalamic area and the paraventricular nucleus, abolished the inhibitory effect of intracerebroventricularly applied bombesin, but a lesion re stricted to the preoptic-anterior hypothalamus or the paraventricular nucleus was without effect. We propose that the preoptic area, the anterior hypothalamus and the paraventricular nucleus are all involved in the inhibitory effect of bombesin on gastric acid secretion.
- 公益社団法人 日本薬理学会の論文
著者
-
OKUMA Yasunobu
Departmen of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
-
Osumi Yoshitsugu
Department Of Pharmacology Faculty Of Medicine Kyoto University
-
Yokotani Kunihiko
Department of Neuropharmacology, Program of Neural Integration, Graduate School of Medicine, Kochi University
関連論文
- Deficits in learning ability and aging of skin in both strains of senescence-accelerated mouse (SAM) P8 and P10 : neuropathological, neurochemical, histological and pharmacological analysis(Chemical & Pharmacological study)
- Age-Related Alterations in the Expression of Glial Cell Line-Derived Neurotrophic Factor in the Senescence-Accelerated Mouse Brain
- Depressive Behavior and Alterations in Receptors for Dopamine and 5-Hydroxytryptamine in the Brain of the Senescence Accelerated Mouse (SAM)-P10
- Roles of the brain phospholipase C, 2-arachidonoylglycerol and arachidonic acid in the central activation of the sympatho-adrenomedullary outflow in rats
- Nicotine-Induced Noradrenaline Release From the Isolated Rat Stomach by Activation of L- and N-type Calcium Channels
- Melatonin Inhibits the Central Sympatho-adrenomedullary Outflow in Rats
- Centrally Applied Nitric Oxide Donors Inhibit Vagally Evoked Rat Gastric Acid Secretion: Involvement of Sympathetic Outflow
- Activation of Ceramidase and Ceramide Kinase by Vanadate via a Tyrosine Kinase–Mediated Pathway
- U-46619, a Selective Thromboxane A_2 Mimetic, Inhibits the Release of Endogenous Noradrenaline From the Rat Hippocampus In Vitro
- Endothelin ET_A- and ET_B-Receptor-Mediated Inhibition of Noradrenaline Release From Isolated Rat Stomach
- Correlation Between Decrease in Protein Levels of Ubiquitin Ligase HRD1 and Amyloid-β Production
- TEK/Tie2 Is a Novel Gene Involved in Endoplasmic Reticulum Stress
- Alteration of Leptin-Induced STAT3 Activation in the Brain of Senescence-Accelerated Mouse (SAM) P8(Pharmacology)
- Aspirin and Sodium Salicylate Protect Brain Cell Death Against Endoplasmic Reticulum Stress
- Possible Role of Interleukin-6 in PC12 Cell Death Induced by MPP^+ and Tetrahydroisoquinoline
- Cholecystokinin Inhibits Food Intake Independent of Interleukin-1β Expression in the Brain(Pharmacology)
- Age-Related Alterations in the Expression of Glial Cell Line-Derived Neurotrophic Factor in the Senescence-Accelerated Mouse Brain
- Novel Functions of Ubiquitin Ligase HRD1 With Transmembrane and Proline-Rich Domains
- The Age-Related Degeneration of Oligodendrocytes in the Hippocampus of the Senescence-Accelerated Mouse (SAM) P8 : A Quantitative Immunohistochemical Study(Pharmacology)
- Role of K^+ Channels in M_2 Muscarinic Receptor-Mediated Inhibition of Noradrenaline Release From the Rat Stomach
- Extracellular Signal Regulated Protein Kinase and c-Jun N-Terminal Kinase are Involved in m1 Muscarinic Receptor-Enhanced Interleukin-2 Production Pathway in Jurkat Cells
- Involvement of N-Type Voltage-Activated Ca^ Channels in the Release of Endogenous Noradrenaline from the Isolated Vascularly Perfused Rat Stomach
- Centrally Applied Bombesin Increases Nerve Activity of Both Sympathetic and Adrenal Branch of the Splanchnic Nerves
- SYMPATHO-ADRENOMEDULLARY SYSTEM-MEDIATED CENTRAL REGULATION OF GASTRIC FUNCTION : ROLES OF CENTRAL NEUROTRANSMITTER CANDIDATES
- Senescence-Accelerated Mouse (SAM) as an Animal Model of Senile Dementia: Pharmacological, Neurochemical and Molecular Biological Approach
- TEK/Tie2 Is a Novel Gene Involved in Endoplasmic Reticulum Stress
- EFFECTS OF DESTRUCTION OF CENTRAL NORADRENERGIC PATHWAYS ON PITUITARY-ADRENOCORTICAL FUNCTIONS IN RATS
- Endogenously generated 2-arachidonoylglycerol plays on inhibitory role in the bombesin-induced activation of central adrenomedullary outflow in rats
- AGE-DEPENDENCE OF THE CHRONOTROPIC RESPONSE TO NORADRENALINE, ACETYLCHOLINE AND TRANSMURAL STIMULATION IN ISOLATED RABBIT ATRIA
- DEVELOPMENT OF REGIONAL ACTIVITIES OF 2', 3'-CYCLIC NUCLEOTIDE 3'-PHOSPHOHYDROLASE AND CARBONIC ANHYDRASE IN THE RAT BRAIN : INFLUENCE OF 6-HYDROXYDOPA
- 6-HYDRXYDOPA-INDUCED STIMULATION OF ORNITHINE DECARBOXYLASE ACTIVITY IN THE DEVELOPING RAT BRAIN
- THE EFFECT OF PIPERIDINE AND PIPECOLIC ACID ON HIGH POTASSIUM-INDUCED RELEASE OF NORADRENALINE, SEROTONIN AND GABA FROM RAT BRAIN SLICES
- INFLUENCE OF PIPERIDINE AND PIPECOLIC ACID ON THE UPTAKE OF MONOAMINES, GABA AND GLYCINE INTO P_2 FRACTIONS OF THE RAT BRAIN AND THE SPINAL CORD
- Axonal transport of transmitter and related enzyme in regeneration of rat sciatic nerves.
- PREVENTIVE EFFECT OF FUSARIC ACID, A DOPAMINE β-HYDROXYLASE INHIBITOR, ON THE GASTRIC ULCERATION INDUCED BY WATER-IMMERSION STRESS IN RATS
- LEVELS OF TYROSINE AND TRYPTOPHAN IN THE PLASMA AND BRAIN OF SPONTANEOUSLY HYPERTENSIVE RATS
- THE CONVERSION OF EXOGENOUSLY ADMINISTERED L-DOPA TO DOPAMINE IN THE STOMACH AND LIVER OF RATS
- CENTRAL CHOLINERGIC ACTIVATION BY CHLORFEN VINPHOS, AN ORGANOPHOSPHATE, IN THE RAT
- Involvement of μ-Receptor in Endogenous Opioid Peptide-Mediated Inhibition of Acetylcholine Release From the Rat Stomach
- Expression of the Ubiquitin Ligase HRD1 in Neural Stem/Progenitor Cells of the Adult Mouse Brain
- Roles of Muscarinic Acetylcholine Receptors in Interleukin-2 Synthesis in Lymphocytes
- Microinjection of α-Calcitonin Gene-Related Peptide into the Hypothalamus Activates Sympathetic Outflow in Rats
- Activation of Ceramidase and Ceramide Kinase by Vanadate via a Tyrosine Kinase-Mediated Pathway
- Correlation Between Decrease in Protein Levels of Ubiquitin Ligase HRD1 and Amyloid-β Production
- Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer's Disease : Possible Involvement of HRD1, a Novel Molecule Related to Endoplasmic Reticulum Stress, in Alzheimer's Disease
- Expression of the Ubiquitin Ligase HRD1 in Neural Stem/Progenitor Cells of the Adult Mouse Brain
- Effects of Hsp90 inhibitors, geldanamycin and its analog, on ceramide metabolism and cytotoxicity in PC12 cells
- Possible Involvement of Ubiquitin Ligase HRD1 Insolubilization in Amyloid .BETA. Generation
- Protective Effects of 4-Phenylbutyrate Derivatives on the Neuronal Cell Death and Endoplasmic Reticulum Stress
- Involvement of Nicotinic Receptors in the Dorsal Motor Nucleus of the Vagus in Regulation of Gastric Motility in Rats.
- Central cholinergic descending pathway to the dorsal motor nucleus of the vagus in regulation of gastric functions.
- Central site of inhibitory action of bombesin on gastric acid secretion in rats.
- Central inhibition of gastric motility by intravenously administered nicotine in rats.
- Enhancement of gastric acid output and mucosal blood flow by tripeptide thyrotropin releasing hormone microinjected into the dorsal motor nucleus of the vagus in rats.
- Effect of d-nicotine on the l-nicotine-induced increase in gastric acid secretion in rats.
- Effects of DJ-7141, a new peripherally acting alpha-2 adrenoceptor agonist, on blood pressure and gastric acid output in rats : Evidence for the heterogeneity of alpha-2 adrenoceptors in different organs.
- Dual effects on gastric acid secretion of electrical stimulation of anterior parts of the rat hypothalamus.
- Stimulatory and Inhibitory Roles of Brain 2-Arachidonoylglycerol in Bombesin-Induced Central Activation of Adrenomedullary Outflow in Rats
- Discovery of Synthetic Methoxy-substituted 4-Phenylbutyric Acid Derivatives as Chemical Chaperones