Involvement of N-Type Voltage-Activated Ca^<2+> Channels in the Release of Endogenous Noradrenaline from the Isolated Vascularly Perfused Rat Stomach
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概要
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We characterized the voltage-activated Ca2+ channels involved in noradrenaline (NA) release from gastric sympathetic neurons using isolated, vascularly perfused rat stomach. The evoked NA release by electrical stimulation of periarterial nerves was abolished by calcium removal from the perfusion medium and by cadmium. ω-Conotoxin GVIA (N-type Ca2+-channel blocker) effectively and ω-conotoxin MVIIC (N/P/Q-type blocker) slightly inhibited the evoked NA, while ω-agatoxin IVA (P-type blocker) had no effect. These results suggest that ω-conotoxin GVIA and ω-conotoxin MVIIC-sensitive N-type Ca2+ channels are involved in NA release from the rat gastric sympathetic nerve terminals.
- 社団法人 日本薬理学会の論文
著者
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OKUMA Yasunobu
Departmen of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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YOKOTANI Kunihiko
Department of Pharmacology, School of Medicine, Kochi University
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Yokotani K
Kochi Medical School Kochi Jpn
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Yokotani Kunihiko
Department Of Pharmacology Kochi Medical School
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OSUMI Yoshitsugu
Department of Pharmacology, Kochi Medical School
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Okuma Y
Hokkaido Univ. Sapporo Jpn
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Okuma Yasunobu
Department Of Pharmacology Kochi Medical School
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Yokotani K
Department Of Pharmacology Kochi Medical School
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Osumi Yoshitsugu
Department Of Pharmacology Kochi Medical School
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Osumi Yoshitsugu
Department Of Pharmacology Faculty Of Medicine Kyoto University
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Yokotani Kunihiko
Department of Neuropharmacology, Program of Neural Integration, Graduate School of Medicine, Kochi University
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