Effect of d-nicotine on the l-nicotine-induced increase in gastric acid secretion in rats.
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概要
- 論文の詳細を見る
d-Nicotine (1000 μg) applied into the cerebral ventricle of urethane anesthetized rats increased gastric acid secretion. When 50 μg of d-nicotine was concomitantly administered with 5μg of I-nicotine, the I-nicotine-induced increases in gastric secretion was blocked. The appearance of convulsion induced by I-nicotine in mice was also inhibited by pretreatment with d-nicotine. These results suggest that d-nicotine has agonistic and antagonistic actions to I-nicotine in the central nervous system and that its agonistic potency varies with preparations.
- 公益社団法人 日本薬理学会の論文
著者
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Nagata Mitsuhiro
Department Of Pharmacology Kansai Medical School
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Osumi Yoshitsugu
Department Of Pharmacology Faculty Of Medicine Kyoto University
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Ishikawa Toshio
Department Of Mind-body Medicine Kohnodai Hospital National Center Of Neurology And Psychiatry
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ISHIKAWA Toshio
Department of Pharmacology, Kochi Medical School
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