INFLUENCE OF TRIMETAZIDINE ON THE INOTROPIC ACTION OF STROPHANTHIN-G ON GUINEA-PIG ATRIA IN ABNORMAL ION ENVIRONMENTS
スポンサーリンク
概要
- 論文の詳細を見る
Trimetazidine, 1-(2,3,4-trimethoxybenzyl) piperazine, was examined in relation to its influence on the inotropic action of strophanthin-G in electrically driven isolated guinea-pig atria. Trimetazidine slightly diminished the effect of strophanthin-G in high Ca, high K, and low K media as well as in Locke's solution. The early stage reduction of the effect of strophanthin-G caused by a low Ca medium was prevented by the presence of trimetazidine. In a low Na medium, the effect of strophanthin-G was manifested by trimetazidine. From these results, it may be assumed that trimetazidine augments the posi-tive inotropic action of strophanthin-G through its prevention of the loss of available calcium ions in atria kept in a low Ca or low Na medium.
- 社団法人日本循環器学会の論文
- 1972-11-20
著者
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Sugimoto Jiro
Department Of Pharmacology Kansai Medical School
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Nagata Mitsuhiro
Department Of Pharmacology Kansai Medical School
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KAWAGUCHI KEIKO
Department of Pharmacology, Kansai Medical School
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Kawaguchi Keiko
Department Of Pharmacology Kansai Medical School
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Kawaguchi Keiko
Department of English Communication, Faculty of Engineering, Shibaura Institute of Technology
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