INCREASE IN Ca^<2+> (Mg^<2+>)-ATPase ACTIVITY INDUCED BY A MOLSIDOMINE DERIVATIVE (SIN-1A) AND NITROGLYCERIN IN MICROSOMAL FRACTION OF GUINEA-PIG THORACIC AORTA

概要

論文の詳細を見る
The amount of phosphoric acid liberated from ATP by Ca^<2+> (Mg^<2+>)-ATPase in microsomal fraction of guinea-pig thoracic aorta decreased with decreasing concentrations of calcium ions from 20.0 to 2.5 mM in the mixture of the enzyme and substrate. When CaCl_2 (2.5 mM) and MgCl_2 (5.0 mM) were present in the substrate, both nitroglycerin (0.1 to 1.0 mM) and SIN-1 A (a molsidomine derivative, 0.05 to 1.0 mM) increased the liberated phosphoric acid in a concentration-dependent manner. The contractile tension of smooth muscle prepared form guinea-pig thoracic aorta, which was previously increased by the pretreatment with prostaglandin F_<2α> (5.0 μM), was relaxed by both nitroglycerin and SIN-1 A (0.01 to 100 μM each) in a concentration-dependent manner. From the results, it is assumed that the stimulation of Ca^<2+> (Mg^<2+>)-ATPase [Ca^<2+>-pump ATPase] activity induced by nitroglycerin and SIN-1 A in the microsome of thoracic aorta takes part in the relaxation of contractile tension in the tissue.
社団法人日本循環器学会の論文
1984-10-20