<Originals>Influence of Magnesium Ions on Calcium-influx and Release of Tissue Calcium Ions in the Smooth Muscle of Isolated Guinea-pig Vas Deferens
スポンサーリンク
概要
- 論文の詳細を見る
Influence of magnesium ions on the calcium-influx and release of tissue calcium ions in the smooth muscle was examined in the contraction of isolated guinea-pig vas deferens. The influence on the calcium-influx was assumed from the effects of the ions on the calcium-induced contraction, which is concentration-dependently contracted bv added calcium ions in the preparation pretreated with tetrasodium edetate and then kept in an isotonic sucrose medium. The contraction was increased by the presence of magnesium ions (0.01-0.1 mmol/l) in the medium, while decreased by the ions (10.0-20.0 mmol/l). The influence of the ions on the release of tissue calcium ions was assumed from the effects of the ions on the potassium-induced contraction, which is concentration-dependently contracted by added potassium ions in the preparation kept in the sucrose medium without the edetate-pretreatment, as the contraction occurs in the calciumfree medium. The magnesium ions (0.01 mmol/l) showed a tendency to increase the contraction, while the ions (0.1-10.0 mmol/l) competitively suppressed it and decreased the maximum contraction. These may suggest that a small amount of magnesium ions promote the calcium-influx and release of tissue calcium ions but a large amount of the ions suppress them. The contraction induced by norepinephrine in the preparation kept in Locke's solution was increased by magnesium ions (0.1 mmol/l) while decreased by high concentrations of the ions such as 5.0-20.0 mmol/l. From the results, the relation between the influence of the ions on the movement of calcium ions in the smooth muscle contraction and that on the norepinephrine-induced contraction was discussed.
- 近畿大学の論文
- 1979-09-28
著者
-
Sugimoto Jiro
Department Of Pharmacology Kansai Medical School
-
Kajimoto Noriyoshi
Department Of Pharmacology Kinki University School Of Medicine
-
Hanasaki Kouichi
Department Of Urology Kansai Medical School
-
TAKEMOTO Hitomi
Department of Pharmacology, Kansai Medical School
-
Takemoto Hitomi
Department Of Urology Kansai Medical School
関連論文
- Role of ATP and Related Purine Compounds on Urethral Relaxation in Male Rabbits
- A POSSIBLE MECHANISM OF INFERTILITY BY ACUTE CADMIUM INTOXICATION
- Contractile Mechanism of ATP in Isolated Vas Deferens of Guinea Pigs
- COMPARATIVE STUDIES ON THE PHARMACOLOGICAL ACTIONS OF ANTI-ARRHYTHMICS IN ISOLATED GUINEA-PIG ATRIA
- Strophanthin-G Toxicity and Sodium Ions
- THE EFFECT OF THIAMINE TETRAHYDROFURFURYLDISULFIDE AGAINST POTASSIUM LOSS IN ISOLATED GUINEA-PIG ATRIA
- Influence of Magnesium Ions on Calcium-influx and Release of Tissue Calcium Ions in the Smooth Muscle of Isolated Guinea-pig Vas Deferens
- Calcium-induced Contraction in the Isolated Guinea-Pig Vas Deferens Pretreated with Tetrasodium Edetate
- BIOTRANSFORMATION OF THIAMINE TETRAHYDROFURFURYLDISULFIDE AND ITS EFFECT ON POTASSIUM LOSS IN ISOLATED GUINEA-PIG ATRIA
- THE ROLE OF CALCIUM, POTASSIUM AND SODIUM IONS ON THE NORADRENALINE INDUCED CONTRACTION IN THE VAS DEFERENS ISOLATED FROM GUINEA-PIGS
- INFLUENCE OF POTASSIUM IONS ON CONTRACTION OF THE VAS DEFERENS ISOLATED FROM GUINEA-PIG
- INFLUENCE OF TRIMETAZIDINE ON THE INOTROPIC ACTION OF STROPHANTHIN-G ON GUINEA-PIG ATRIA IN ABNORMAL ION ENVIRONMENTS
- INFLUENCE OF CALCIUM AND SODIUM IONS ON POTASSIUM INDUCED CONTRACTION IN ISOLATED GUINEA-PIG VAS DEFERENS KEPT IN SUCROSE MEDIUM
- THE INFLUENCE OF THIAMINE TETRAHYDROFURFURYLDISULFIDE AGAINST STROPHANTHIN-G TOXICITY IN GUINEA-PIG ATRIA
- Metabolism and Calcium Antagonism of Sodium Alginate Oligosaccharides
- INCREASE IN Ca^ (Mg^)-ATPase ACTIVITY INDUCED BY A MOLSIDOMINE DERIVATIVE (SIN-1A) AND NITROGLYCERIN IN MICROSOMAL FRACTION OF GUINEA-PIG THORACIC AORTA
- THE ACTIONS OF TRIMETAZIDINE ON ISOLATED GUINEA-PIG ATRIA
- PHARMACOLOGICAL STUDIES ON FIBRILLATION VOLTAGES IN DENERVATED SKELETAL MUSCLE OF RABBIT
- Reactivity to receptor and Ca2+ availability in vascular smooth muscle from SHRSP
- Responses of isolated renal arteries in SHRSP to vasodilators and transmural electrical stimulation
- Relaxant Response of Isolated Basilar Arteries to Calcitonin Gene-Related Peptide in Stroke-Prone Spontaneously Hypertensive Rats.