Metabolism and Calcium Antagonism of Sodium Alginate Oligosaccharides
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概要
- 論文の詳細を見る
Sodium alginate oligosaccharides (NaAOs) consisting of a mixture of eight oligosaccharides have previously been reported to lower blood pressure. We investigated in this study the excretion of NaAOs into the urine or feces, and attempted to elucidate the mechanism for lowering blood pressure by using isolated mesenteric arteries from the rabbit. The recovery rate of P8, which is the main component of NaAOs, was 5.2% and 58.9% over 48 hours in the urine and feces, respectively. The mechanism for lowering blood pressure appeared to be NaAOs having calcium antagonist activity, especially voltage-operated calcium channels. Our results suggest that NaAOs are substantially excreted into the feces, although some of them may be absorbed internally, exerting antagonist activity towards the calcium channels, especially voltage-operated calcium channels.
- 社団法人 日本農芸化学会の論文
- 2007-08-23
著者
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Ogawa Hiroshi
Department Of Anatomy And Neurobiology Kyoto Prefectural University Of Medicine
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Kajimoto Noriyoshi
Department Of Pharmacology Kinki University School Of Medicine
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Hiura Nozomi
Central Research Institute Maruha Group Inc.
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Baba Takashi
Central Res. Inst. Maruha Group Inc.
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CHAKI Takamitsu
Central Research Institute, Maruha Group Inc.
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Chaki Takamitsu
Central Res. Inst. Maruha Group Inc.
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Chaki Takamitsu
Central Research Institute Maruha Group Inc.
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Ogawa Hiroshi
Tezukayamagakuin Univ.
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BABA Takashi
Central Research Institute, Maruha Group Inc.
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