COMPARATIVE STUDIES ON THE PHARMACOLOGICAL ACTIONS OF ANTI-ARRHYTHMICS IN ISOLATED GUINEA-PIG ATRIA

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Ajmaline, cocaine, diphenylhypantoin, lidocaine, procainamide, propranolol, quinidine, and trimetazidine were comparatively examined as to their actions in isolated guinea-pig atria on the beat rate of their spontaneous contractions and on their contractile tension and their functional refractory period. All the drugs except diphenylhydantoin could increase the functional refractory period. When the influence of each drug on beat rate or contractile tension was compared at the concentrations in which each could prolong the refractory period to twice that of the controls, lidocaine, procainamide, propranolol, and quinidine were found to decrease the tension by more than 60% but the beat rate by less than 60% of those of the respective controls. Ajmaline, however, was found to reduce the beat rate by 20% of that of the control already at a concentration by which the refractory period of atrial muscle would begin to be increased by this drug. Cocaine and trimetazidine were found to have a relatively stronger effect on the refractory period than they did on the beat rate or the contractile tension.
社団法人日本循環器学会の論文
1973-09-20