COMPARATIVE STUDY OF THE EFFECTS OF STRYCHNINE AND MEGIMIDE ON THE REFLEX ACTIVITIES OF SPINAL CORD IN RABBIT
スポンサーリンク
概要
- 論文の詳細を見る
Concerning the mechanism of action of strychnine on the central nervous system, Dusser de Barenne (1) and others have made various reports. Recently Bradley <I>et al</I>. (2) and Eccles (3) observing strychnine suppresses the direct inhibitory action and depresses the polysynaptic inhibition in the spinal cord through electrophysiological studies have expressed a new opinion that this is related to the mode of central excitatory action of strychnine.<BR>Morita <I>et al</I>. (4) caught the muscle discharge originating in Golgi's tendon organ. which has been considered to be inhibitory on motoneuron in the spinal cord. Next, Takeuchi (5), one of our colleagues investigated the effects of ether, barbiturate and myanesin on this discharge and other spinal reflex discharges and Kimura (6) that of chlorpromazine on these muscle discharges. We have been able to observe two or three discharges at the same time when the same methods as described in the previous reports were used. Accordingly, we have considered it significant to investigate the mechanism of strychnine action on the spinal cord in the electromyography of rabbit's hindlimb.<BR>It was found by Shaw <I>et al</I>. (7) that megimide (β-β-ethyl-methyl glutarimide) has an antagonism towards barbiturates, and Cass (8) comparing megimide with picrotoxin or pentylenetetrazol to its potency of antagonistic action against barbiturates, concluded that megimide is more effective barbiturate antagonist than these analeptics. It has generally been said that such medullary stimulants have different loci of action from that of strychnine and though strychnine produces predominant responses by the functional changes of neuron in the spinal cord, on the contrary, medullary stimulants have strong action at a higher center than the spinal level. Therefore, the authors studying the comparative effect of strychnine and megimide on spinal reflex activities, have tried to discover the difference in spinal action of these two drugs.
- 公益社団法人 日本薬理学会の論文
著者
-
Ito Chieko
Department Of Internal Medicine Nagoya City University Medical School
-
MORITA Masao
Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering, Yamaguchi University
-
MORITA MASAO
Department of Pharmacology, Kansai Medical School
-
Kimura Toshiko
Department of Nursing, Hirosaki University Hospital
-
KIMURA TOSHIKO
Department of Pharmacology, Kansai Medical School
-
YASUHARA MOTOHIRO
Department of Pharmacology, Kansai Medical School
-
KITAO NORIKO
Department of Pharmacology, Kansai Medical School
-
YASUHARA MOTOHIRO
Department of Pharmacology, Faculty of Medicine, Kyoto University
関連論文
- COMPARATIVE STUDIES ON THE PHARMACOLOGICAL ACTIONS OF ANTI-ARRHYTHMICS IN ISOLATED GUINEA-PIG ATRIA
- Strophanthin-G Toxicity and Sodium Ions
- INCREASE IN Ca^ (Mg^)-ATPase ACTIVITY INDUCED BY A MOLSIDOMINE DERIVATIVE (SIN-1A) AND NITROGLYCERIN IN MICROSOMAL FRACTION OF GUINEA-PIG THORACIC AORTA
- CLINICAL INVESTIGATIONS ON EPIDEMIC HEPATITIS : REPORT II. STUDIES ON THE DYE-TEST (HEPATOSULPHALEIN TEST) FOR EXCRETORY FUNCTION OF THE LIVER, AND ON THE CADMIUM REACTION
- Identification and Antimicrobial Susceptibility of Enterococci Isolated from Dogs and Cats Subjected to Differing Antibiotic Pressures
- Role of Nurses in Early Ambulation of Living Donor Liver Transplant Recipients [Innovation in Transplant and Regenerative Medicine. The 13th Meeting of Hirosaki International Forum of Medical Science. Communication Center of Hirosaki University School of
- COMPARATIVE STUDY OF THE EFFECTS OF STRYCHNINE AND MEGIMIDE ON THE REFLEX ACTIVITIES OF SPINAL CORD IN RABBIT
- ELECTROMYOGRAPHIC STUDIES OF EFFECTS OF CHLORPROMAZINE ON NOCICEPTIVELY AND PROPRIOCEPTIVELY INDUCED REFLEX PATTERN OF RABBIT'S HINDLIMB
- PHARMACOLOGICAL STUDIES ON FIBRILLATION VOLTAGES IN DENERVATED SKELETAL MUSCLE OF RABBIT
- STUDIES ON SITES OF ACTION OF ANALGESICS:1. THE EFFECT OF ANALGESICS ON AFFERENT PATHWAYS OF SEVERAL NERVES
- STUDIES ON SITES OF ACTION OF ANALGESICS:2. THE EFFECT OF ANALGESICS ON AFFERFNT PATHWAYS OF PAIN